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本文引用的文献

1
Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation.线索诱发的可卡因复吸依赖于快速、短暂的突触增强。
Neuron. 2013 Mar 6;77(5):867-72. doi: 10.1016/j.neuron.2013.01.005.
2
Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens.可卡因对伏隔核树突棘的调节中，亚区、树突分支隔室和棘突亚型特异性。
J Neurosci. 2012 May 16;32(20):6957-66. doi: 10.1523/JNEUROSCI.5718-11.2012.
3
The Bermuda Triangle of cocaine-induced neuroadaptations.可卡因诱导的神经适应性的百慕大三角。
Trends Neurosci. 2010 Sep;33(9):391-8. doi: 10.1016/j.tins.2010.06.003. Epub 2010 Jul 23.
4
Neurocircuitry of addiction.成瘾的神经回路。
Neuropsychopharmacology. 2010 Jan;35(1):217-38. doi: 10.1038/npp.2009.110.
5
Altered dendritic spine plasticity in cocaine-withdrawn rats.可卡因戒断大鼠树突棘可塑性改变。
J Neurosci. 2009 Mar 4;29(9):2876-84. doi: 10.1523/JNEUROSCI.5638-08.2009.
6
Review. Context-induced relapse to drug seeking: a review.综述：情境诱导的觅药复吸：一篇综述
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3233-43. doi: 10.1098/rstb.2008.0090.
7
Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats.伏隔核壳部和核心部参与药物环境诱导的大鼠可卡因觅求行为复燃。
Psychopharmacology (Berl). 2008 Nov;200(4):545-56. doi: 10.1007/s00213-008-1234-4. Epub 2008 Jul 4.
8
Renewal of drug seeking by contextual cues after prolonged extinction in rats.大鼠长期消退后由情境线索引发的觅药行为恢复
Behav Neurosci. 2002 Feb;116(1):169-73. doi: 10.1037//0735-7044.116.1.169.
9
Cue reactivity and cue reactivity interventions in drug dependence.药物依赖中的线索反应性及线索反应性干预措施
NIDA Res Monogr. 1993;137:73-95.
10
Role of conditioned contextual stimuli in reinstatement of extinguished fear.条件性情境刺激在消退恐惧恢复中的作用。
J Exp Psychol Anim Behav Process. 1979 Oct;5(4):368-78. doi: 10.1037//0097-7403.5.4.368.

在情境诱导的可卡因觅求复发中树突棘的快速、短暂增强。

Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking.

作者信息

Stankeviciute Neringa M, Scofield Michael D, Kalivas Peter W, Gipson Cassandra D

机构信息

Department of Biology, College of Charleston, Charleston, SC, USA; Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.

出版信息

Addict Biol. 2014 Nov;19(6):972-4. doi: 10.1111/adb.12064. Epub 2013 May 6.

DOI:10.1111/adb.12064
PMID:23648005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3742620/
Abstract

Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.

摘要

可卡因成瘾会在大脑突触生理方面产生持久、稳定的变化，这可能导致复吸易感性增加。在人类中，暴露于先前与药物使用相关的环境中会引发复吸，但介导这一过程的神经生物学机制尚不清楚。通过再次暴露于与药物相关的环境来引发可卡因复吸，会导致可卡因觅求行为的恢复，以及伏隔核核心（NAcore）中快速、短暂的突触可塑性变化，表现为树突棘直径增加。这些结果表明，NAcore中快速的环境诱发突触增强可能是可卡因使用复吸的基础。