在情境诱导的可卡因觅求复发中树突棘的快速、短暂增强。
Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking.
作者信息
Stankeviciute Neringa M, Scofield Michael D, Kalivas Peter W, Gipson Cassandra D
机构信息
Department of Biology, College of Charleston, Charleston, SC, USA; Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.
出版信息
Addict Biol. 2014 Nov;19(6):972-4. doi: 10.1111/adb.12064. Epub 2013 May 6.
Abstract
Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.
摘要
可卡因成瘾会在大脑突触生理方面产生持久、稳定的变化，这可能导致复吸易感性增加。在人类中，暴露于先前与药物使用相关的环境中会引发复吸，但介导这一过程的神经生物学机制尚不清楚。通过再次暴露于与药物相关的环境来引发可卡因复吸，会导致可卡因觅求行为的恢复，以及伏隔核核心（NAcore）中快速、短暂的突触可塑性变化，表现为树突棘直径增加。这些结果表明，NAcore中快速的环境诱发突触增强可能是可卡因使用复吸的基础。
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