Wang J Y
Division of Gastroenterology, Zhongshan Hospital, Shanghai Medical University.
Zhonghua Yu Fang Yi Xue Za Zhi. 1990 Mar;24(2):90-2.
An investigation of the epidemic of hepatitis A which occurred in early 1988 in Shanghai was conducted at the Shanghai Number 2 Yarn Dyeing and Weaving Mill. In this factory the attack rate between January and April 1988 was 9%. The rate was highest among staff and workers who ate raw clams (18%) but also higher among those who ate cooked clams (7%) than among those who did not eat clams (2%). In addition, independent risk factors for infection were: age below 30 years (relative risk = 3.0, 95% confidence interval: 2.0, 4.5) shift work (relative risk = 3.3, 95% confidence interval: 1.9, 5.8) and eating out (relative risk = 4.7, 95% confidence interval: 2.3, 9.7). The consumption of clams contaminated with hepatitis A virus was the main risk factor in this episode. The study indicates that strengthening surveillance of shellfish hygiene is important to prevent future epidemics of hepatitis A.
1988年初在上海甲肝流行期间，对上海第二毛纺织厂进行了调查。1988年1月至4月期间，该厂的发病率为9%。在食用生蛤蜊的职工中发病率最高（18%），但食用熟蛤蜊的职工发病率（7%）也高于未食用蛤蜊的职工（2%）。此外，感染的独立危险因素有：30岁以下（相对危险度=3.0，95%可信区间：2.0，4.5）、倒班工作（相对危险度=3.3，95%可信区间：1.9，5.8）和外出就餐（相对危险度=4.7，95%可信区间：2.3，9.7）。食用被甲型肝炎病毒污染的蛤蜊是此次疫情的主要危险因素。该研究表明，加强贝类卫生监测对于预防未来甲型肝炎的流行非常重要。
