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髌股关节退行性关节炎的实验研究

[Experimental study of degenerative arthritis of the patello-femoral joint].

作者信息

Zhao D L

机构信息

Changzheng Hospital of Second Military Medical College, Shanghai.

出版信息

Zhonghua Wai Ke Za Zhi. 1990 Feb;28(2):69-71, 125.

PMID:2364825
Abstract

In order to investigate the pathological changes and stages of development of degenerative arthritis, a model of degenerative arthritis of patello-femoral joint was established in 30 rabbits by shortening the patellar tendon by 4 mm. The animals were killed 1,2,4,6,8,12 weeks after operation, and the results showed that the compression force between patella and femoral condyle increased 1/4 and a typical change of degenerative arthritis was a observed grossly and histologically and ultrastructurally. The authors consider that this kind of model may be used for further study of prevention and treatment of degenerative arthritis.

摘要

为了研究退行性关节炎的病理变化和发展阶段,通过将髌腱缩短4毫米,在30只兔子身上建立了髌股关节退行性关节炎模型。术后1、2、4、6、8、12周处死动物,结果显示髌骨与股骨髁之间的压力增加了1/4,大体、组织学和超微结构观察均可见典型的退行性关节炎变化。作者认为这种模型可用于进一步研究退行性关节炎的防治。

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