Mazieres B, Blanckaert A, Thiechart M
J Rheumatol. 1987 May;14 Spec No:119-21.
A contusive procedure has been developed for the induction of a predictable and reproducible degenerative joint disease in knees of rabbits. Significant degeneration was observed in patella, condyles, and trochlea. These lesions included fibrillation, ulceration and erosion, clones of chondrocytes, and osteophyte formation. The incidence and distribution of lesions with time following contusion were also investigated. Lesions were observed as early as 1 day post-contusion and increased in number and severity. A global scoring system has been devised to permit comparisons of lesion incidence and severity, specially to test drug efficacy in this model of osteoarthritis.
已开发出一种挫伤程序，用于在兔膝关节中诱导可预测且可重复的退行性关节疾病。在髌骨、髁和滑车中观察到明显的退变。这些病变包括纤维化、溃疡和糜烂、软骨细胞克隆以及骨赘形成。还研究了挫伤后病变随时间的发生率和分布情况。在挫伤后1天就观察到了病变，其数量和严重程度不断增加。已设计出一种综合评分系统，以比较病变的发生率和严重程度，特别是用于测试该骨关节炎模型中药物的疗效。
