Yang Fan, Chen Rong-ping, Song Qing-qing, Chen Li-shu, Lin Shao-da, Liang Gan-xiong, Hu Bao-chun, Zhu Zhi-zhang, Wang Yu-lin, Yan Li, Lin Jian-cai, Li Yan-bing, Cai De-hong
Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Zhonghua Yi Xue Za Zhi. 2013 Jan 8;93(2):104-9.
To explore the glycemic control status and related risk factors of overweight or obesity patients with type 2 diabetes mellitus (T2DM) in Guangdong province.
The medical records of overweight or obesity patients with T2DM from 60 tertiary and secondary hospitals in Guangdong Province were collected by questionnaire and physical examination. And the clinical data were analyzed to explore the influencing factors of glycemic control. The HbA1c level was used to assess glycemic control. HbA1c < 7.0% indicated that glycemic control was up to standard.
From August 2011 to March 2012, 5241 T2DM patients were recruited. The scope of current analysis was restricted to 4768 subjects with true data and deficiency no more than 5%. There were 2252 males and 2516 females. The age range was from 16 to 90 years, a median age 59.0 (50.0 - 69.0) years, onset age of diabetes 52.0 (44.0 - 60.0) years; a range of disease duration from 1 day to 42 years and a median of 5.0 (2.0 - 11.0) years. The median body mass index was 26.33(24.88 - 28.34) kg/m(2) and median waist circumference 93.0 (88.0 - 100.0) cm. Median HbA1c was 8.1% (6.9% - 10.1%) and only 26.2% patients reached the target level of HbA1c < 7.0%. Influencing factors of poor glycemic control were central obesity, high levels of resting heart rate, concurrent fatty liver and high intensity of treatment. And influencing factors of good glycemic control were regular exercises, smoking cessation, regular glycemic monitoring and good control of total cholesterol/triglyceride.
A majority of Guangdong type 2 diabetics fail to achieve target values for glycemic control. There is an urgent need for comprehensive management for improving glycemic control.
探讨广东省超重或肥胖的2型糖尿病（T2DM）患者的血糖控制状况及相关危险因素。
通过问卷调查和体格检查收集广东省60家三级和二级医院超重或肥胖的T2DM患者的病历。并对临床资料进行分析以探究血糖控制的影响因素。采用糖化血红蛋白（HbA1c）水平评估血糖控制情况。HbA1c<7.0%表明血糖控制达标。
2011年8月至2012年3月，共招募了5241例T2DM患者。当前分析范围限于4768例数据真实且缺失不超过5%的受试者。其中男性2252例，女性2516例。年龄范围为16至90岁，中位年龄59.0（50.0 - 69.0）岁，糖尿病发病年龄52.0（44.0 - 60.0）岁；病程范围为1天至42年，中位病程5.0（2.0 - 11.0）年。中位体重指数为26.33（24.88 - 28.34）kg/m²，中位腰围93.0（88.0 - 1百.0）cm。中位HbA1c为8.1%（6.9% - 10.1%），仅有26.2%的患者达到HbA1c<7.0%的目标水平。血糖控制不佳的影响因素为中心性肥胖、静息心率高、合并脂肪肝及治疗强度大。血糖控制良好的影响因素为规律运动、戒烟、定期血糖监测及总胆固醇/甘油三酯控制良好。
广东省大多数2型糖尿病患者未达到血糖控制目标值。迫切需要进行综合管理以改善血糖控制。
