Wang Jiao, Zhang Ru-yi, Chen Rong-ping, Chen Li-shu, Lin Shao-da, Liang Gan-xiong, Hu Bao-chun, Zhu Zhi-zhang, Wang Yu-lin, Yan Li, Lin Jian-cai, Li Yan-bing, Cai De-hong
Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
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Zhonghua Yi Xue Za Zhi. 2013 Sep 24;93(36):2851-6.
To explore the prevalence and risk factors for dyslipidemia in diabetics with overweight or obesity.
Diabetics with overweight or obesity were recruited from 62 tertiary and secondary hospitals in Guangdong Province between August 2011 and March 2012. Dyslipidemia was diagnosed as total cholesterol (TC) ≥ 5.7 mmol/L or triglycerides (TG) ≥ 1.7 mmol/L or low-density-lipoprotein cholesterol (LDL-C) ≥ 3.6 mmol/L or high-density-lipoprotein cholesterol (HDL-C) < 1.29 mmol/L in females or HDL-C < 1.03 mmol/L in males. Binary Logistic regression was used to assess the associations between dyslipidemia and associated risk factors.
Dyslipidemia was detected in 3160/3593 (87.9%) diabetics with overweight or obesity. And the prevalence of hypertriglyceridemia, low blood HDL-C, hypercholesterolemia and high blood LDL-C was 52.5% (1888/3593) , 54.1% (1945/3593), 33.1% (1188/3593) and 27.4% (985/3593) respectively. Among those with dyslipidemia, patients with simple and mixed dyslipidemia accounted for 34.1% and 53.9% respectively. In binary Logistic regression analysis, the presence of dyslipidemia were associated with female gender (OR = 1.593, 95%CI 1.233-2.057), hemoglobinA1c(HbA1c) (OR = 1.120, 95%CI 1.054-1.191), body mass index (OR = 1.084, 95%CI 1.022-1.150), hypertension (OR = 1.331, 95%CI 1.033-1.714), history of diabetes (OR = 1.586, 95%CI 1.186-2.120) and hyperuricacidemia (OR = 2.270, 95%CI 1.642-3.138).
The prevalence of dyslipidemia is quite high in diabetics with overweight or obesity. The controls of blood pressure, serum uric acid level, blood glucose and body weight may reduce the prevalence of dyslipidemia, prevent and delay the development of cardiovascular complications and reduce the mortality of diabetics with overweight or obesity.
探讨超重或肥胖糖尿病患者血脂异常的患病率及危险因素。
2011年8月至2012年3月期间，从广东省62家三级和二级医院招募超重或肥胖糖尿病患者。血脂异常的诊断标准为：总胆固醇（TC）≥5.7 mmol/L或甘油三酯（TG）≥1.7 mmol/L或低密度脂蛋白胆固醇（LDL-C）≥3.6 mmol/L或女性高密度脂蛋白胆固醇（HDL-C）<1.29 mmol/L或男性HDL-C<1.03 mmol/L。采用二元Logistic回归分析评估血脂异常与相关危险因素之间的关联。
3593例超重或肥胖糖尿病患者中，3160例（87.9%）检测出血脂异常。高甘油三酯血症、低HDL-C血症、高胆固醇血症和高LDL-C血症的患病率分别为52.5%（1888/3593）、54.1%（1945/3593）、33.1%（1188/3593）和27.4%（985/3593）。在血脂异常患者中，单纯性血脂异常和混合性血脂异常患者分别占34.1%和53.9%。二元Logistic回归分析显示，血脂异常的发生与女性性别（OR=1.593，95%CI 1.233-2.057）、糖化血红蛋白（HbA1c）（OR=1.120，95%CI 1.054-1.191）、体重指数（OR=1.084，95%CI 1.022-1.150）、高血压（OR=1.331，95%CI 1.033-1.714）、糖尿病病程（OR=1.586，95%CI 1.186-2.120）和高尿酸血症（OR=2.270，95%CI 1.642-3.138）有关。
超重或肥胖糖尿病患者血脂异常的患病率相当高。控制血压、血清尿酸水平、血糖和体重可能会降低血脂异常的患病率，预防和延缓心血管并发症的发生，降低超重或肥胖糖尿病患者的死亡率。
