通过 Cs2CO3 促进的芳基迁移过程形成多取代季铵咪唑的新型级联策略。
A novel domino strategy for forming poly-substituted quaternary imidazoles through a Cs2CO3-promoted aryl migration process.
机构信息
School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, 211116, P. R. China.
出版信息
Org Biomol Chem. 2013 Jun 14;11(22):3603-7. doi: 10.1039/c3ob40666k.
A new domino strategy for the synthesis of highly functionalized quaternary imidazole derivatives via [3 + 2] heterocyclization, involving aryl migration and ring-opening of oxirane, has been developed. This domino reaction enables the successful assembly of three new sigma bonds including two C-N bonds in a simple operation. Features of this strategy include the mild conditions, convenient operation, and short reaction periods (15-20 min).
一种通过[3+2]杂环化反应，包括芳基迁移和环氧开环，合成高度官能化的季咪唑衍生物的新型多米诺策略已经被开发出来。该多米诺反应能够在一个简单的操作中成功地组装三个新的σ键，包括两个 C-N 键。该策略的特点包括温和的条件、方便的操作和较短的反应时间（15-20 分钟）。
Zotero 插件