Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.
J Alzheimers Dis. 2013;36(4):659-63. doi: 10.3233/JAD-130323.
Neuroglobin is a neuronal protein with protective effects in animal models of stroke and Alzheimer's disease, but the relevance of these effects to Alzheimer's disease in humans is unknown. We measured neuroglobin levels by western blot and immunostained hippocampal sections for neuroglobin, cell-type protein markers, and amyloid-β, in brain tissue obtained at autopsy from patients with Alzheimer's disease. Neuroglobin levels were increased in early and moderately advanced Alzheimer's disease compared to controls, but declined to control levels in severe disease. In patients with Alzheimer's disease, neuroglobin was detected within neurons, as well as at extracellular sites associated with amyloid-β deposits. We conclude that, as in transgenic mouse models, neuroglobin may influence the course of clinical Alzheimer's disease.
神经球蛋白是一种具有神经保护作用的神经元蛋白，在中风和阿尔茨海默病的动物模型中具有保护作用，但这些作用与人类阿尔茨海默病的相关性尚不清楚。我们通过 Western blot 测量了神经球蛋白水平，并对尸检获得的脑组织中海马切片进行了神经球蛋白、细胞型蛋白标志物和淀粉样β的免疫染色，这些组织来自阿尔茨海默病患者。与对照组相比，早期和中度阿尔茨海默病患者的神经球蛋白水平升高，但在重度疾病中降至对照组水平。在阿尔茨海默病患者中，神经球蛋白不仅在神经元内被检测到，而且在与淀粉样β沉积相关的细胞外部位也被检测到。我们的结论是，与转基因小鼠模型一样，神经球蛋白可能影响临床阿尔茨海默病的病程。
