Stroke. 2010 Mar;41(3):557-9. doi: 10.1161/STROKEAHA.109.567149. Epub 2010 Jan 14.
We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke.
Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke.
Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke.
Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy.
我们研究了神经元蛋白神经球蛋白是否在缺血性脑卒中患者中上调,这种蛋白可以保护神经元免受缺氧缺血损伤。
检测了对照组和缺血性脑卒中患者脑组织中的神经球蛋白免疫反应性。
神经球蛋白在多个脑区被检测到,并且在脑卒中后皮质梗死周边区的表达增加。
缺血性脑卒中增加了神经保护蛋白神经球蛋白的表达,提示神经球蛋白可能成为脑卒中治疗的新靶点。