Ciccone Lidia, Nencetti Susanna, Socci Simone, Orlandini Elisabetta
Department of Pharmacy, University of Pisa, Pisa, Italy.
Department of Earth Sciences, University of Pisa, Pisa, Italy.
Neural Regen Res. 2021 Dec;16(12):2353-2358. doi: 10.4103/1673-5374.300981.
Neuroglobin (Ngb) is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin family. Ngb is mainly expressed in neurons of the central and peripheral nervous system, although moderate levels of Ngb have been detected in non-nervous tissues. In the past decade, Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer's disease, Huntington's disease, brain ischemia and hypoxia. This review discusses and summarizes the natural compounds and the small synthetic molecules capable of modulating Ngb expression that exhibits a protective role against various neurodegenerative diseases.
神经球蛋白（Ngb）是一种17千道尔顿的单体六配位血红素蛋白，属于球蛋白家族。Ngb主要在中枢和外周神经系统的神经元中表达，尽管在非神经组织中也检测到了中等水平的Ngb。在过去十年中，人们对Ngb在大量神经疾病如阿尔茨海默病、亨廷顿病、脑缺血和缺氧中的神经保护作用进行了研究。本文综述并总结了能够调节Ngb表达的天然化合物和小型合成分子，这些化合物和分子对各种神经退行性疾病具有保护作用。
