Ras信号触发β-淀粉样前体蛋白（APP）的表达。
Ras signal triggers β-amyloid precursor protein (APP) expression.
作者信息
Mora Natalia, Santa Bárbara Ruiz Paula, Ferreira Nuno, Serras Florenci
机构信息
Departament de Genètica; Facultat de Biologia; Institut de Biomedicina de la Universitat de Barcelona (IBUB); Universitat de Barcelona; Barcelona, Spain; Laboratory of Neurogenetics; Department of Molecular and Developmental Genetics; VIB; Leuven, Belgium.
Departament de Genètica; Facultat de Biologia; Institut de Biomedicina de la Universitat de Barcelona (IBUB); Universitat de Barcelona; Barcelona, Spain.
出版信息
Small GTPases. 2013 Jul-Sep;4(3):171-3. doi: 10.4161/sgtp.24768. Epub 2013 May 6.
Abstract
It has recently been discovered that the Drosophila β-amyloid protein precursor like (Appl) gene, the ortholog of the human β-Amyloid Precursor Protein (APP) gene, is transcriptionally activated by receptor tyrosine kinase activity that involves Ras/MAPK signaling in vivo. This regulation is specifically controlled in photoreceptor neurons of the Drosophila retina. This suggests that some cases of Alzheimer disease, those which have been associated with high expression of the APP gene, may involve Ras signal transduction.
摘要
最近发现，果蝇β-淀粉样蛋白前体样（Appl）基因，即人类β-淀粉样前体蛋白（APP）基因的直系同源基因，在体内可被涉及Ras/丝裂原活化蛋白激酶（MAPK）信号传导的受体酪氨酸激酶活性转录激活。这种调节在果蝇视网膜的感光神经元中受到特异性控制。这表明，阿尔茨海默病的某些病例，那些与APP基因高表达相关的病例，可能涉及Ras信号转导。
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