成人新诊断的癫痫发作

Ismail Hassan M, Al-Sulaiman Abdulsalam A, Abolenin Alaeddin A, Al-Shammary Shoaa, Al-Khamis Fahd, Al-Qulaiti Khalid, Abumadini Mahdi S

Department of Neurology, King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia.

Neurosciences (Riyadh). 2003 Apr;8(2):104-6.

OBJECTIVE

To study the clinical, electroencephalographic (EEG) and computed tomography (CT) profile in a hospital population of over 18-years adult patients with newly diagnosed recurrent seizures.

METHODS

The clinical profiles obtained from history including detailed description of the seizures, examination, EEG and CT findings were recorded prospectively for all over-18 patients who were referred to the electrodiagnostic service at King Fahd Hospital of the University, Al-Khobar, Eastern Province, Kingdom of Saudi Arabia from January 1, 1996 to December 31, 1997. The data was entered into a standard database file and analyzed using a personal computer.

RESULTS

Seventy-three patients (43 males, 30 females, mean age 32.3 years) with newly diagnosed recurrent seizures were studied. A positive family history of seizures was found in 12.3%. The main seizure types were partial in 27 (37%), partial with secondary generalization in 22 (30.1%) and generalized in 24 (32.9%). The types of epileptic syndromes included localization-related 34 (46.6%), generalized 24 (32.9%) and undetermined 15 (20.5%). The EEG was abnormal in 45 (61.6%) with epileptiform activity, focal in 22 (48.9%), generalized in 11 (24.4%) and non-epileptiform activity in 12 (26.7%). The cranial CT findings were normal in 44 patients (60.3%) and abnormal in 29 (39.7%) patients, with focal lesions in 19 (65.5%) and generalized cerebral atrophy in 10 (34.5%).

CONCLUSION

Our results showed that partial and partial with secondary generalization seizures are the most frequent seizure type and the most common epileptic syndrome was the localization-related type in this age group. These results are comparable to previous population- and hospital-based western reports.

目的

研究沙特阿拉伯王国东部省胡巴尔市法赫德国王大学医院中18岁以上新诊断为复发性癫痫患者的临床、脑电图（EEG）及计算机断层扫描（CT）特征。

方法

前瞻性记录了1996年1月1日至1997年12月31日期间转诊至法赫德国王大学医院电诊断科的所有18岁以上患者的临床资料，包括发作的详细描述、检查、EEG及CT检查结果。数据录入标准数据库文件，并使用个人计算机进行分析。

结果

对73例新诊断为复发性癫痫的患者（43例男性，30例女性，平均年龄32.3岁）进行了研究。12.3%的患者有癫痫家族史阳性。主要发作类型为部分性发作27例（37%），部分性发作继发全面性发作22例（30.1%），全面性发作24例（32.9%）。癫痫综合征类型包括局灶性相关型34例（46.6%），全面性24例（32.9%），未定型15例（20.5%）。EEG异常45例（61.6%），有癫痫样放电，局灶性22例（48.9%），全面性11例（24.4%），非癫痫样放电12例（26.7%）。头颅CT检查结果44例（60.3%）正常，29例（39.7%）异常，局灶性病变19例（65.5%），广泛性脑萎缩10例（34.5%）。