青少年新诊断癫痫发作：一项对比研究。

Newly diagnosed seizures in adolescents: a comparative study.

作者信息

Ismail Hassan M

机构信息

King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.

出版信息

J Family Community Med. 2003 May;10(2):37-42.

PMID:23011990

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3425765/

Abstract

OBJECTIVE

To study the clinical, EEG and CT profile in a hospital population of adolescents with newly diagnosed recurrent seizures.

METHODS

The clinical profiles obtained from history including detailed descriptions of the seizures, examination, electroencephalographic (EEG) and computed tomography (CT) findings were recorded prospectively for all 14 to18-year-old patients who were referred to the electrodiagnostic service at King Fahd Hospital of the University, Al- Khobar, Eastern Province, Saudi Arabia from 1(st) January 1996 to 31(st) December 1997. The data were entered into a standard dbase file and analyzed using a personal computer. The results were compared with 2 previous concomitant subsets of data obtained from 263 children ≤13 years (72%) and 73 adults > 18 years (20%) over the same study period.

RESULTS

Twenty-nine patients (14 males and 15 females, a mean age of 15.7 years) with newly diagnosed recurrent seizures were studied. A positive family history of seizures was found in 10.3%. The main seizure types were partial in 11 (37.9%), partial with secondary generalization in 6 (20.7%) and generalized in 12 (41.4%). The types of epileptic syndromes included localization-related 15 (51.7%), generalized 12 (41.4%) and undetermined 2 (16.9%). The EEG was abnormal in 21 (72.4%) with epileptiform activity, focal in 11 (52.4%), generalized in 9 (42.8%) and none-epileptiform activity in 1 (4.8%). The cranial CT findings were normal in 21 patients (72.4%) and abnormal in 8 (27.6%) patients, with focal lesions in 6 (75%) and generalized cerebral atrophy in 2 (25%). The frequency of adolescents presenting with newly-diagnosed seizures was 8% of the total study population of 365 patients including children and adults.

CONCLUSION

The results showed that partial and partial with secondary generalization seizures and the localization-related epileptic syndrome are the most frequent seizure and epileptic syndrome types in adolescents. The least frequent of newly diagnosed seizures in adolescents compared to children and adults confirms the bimodality of peak frequency in the young and old that has been observed in the west.

摘要

目的

研究新诊断为复发性癫痫发作的青少年住院患者的临床、脑电图及CT特征。

方法

前瞻性记录了1996年1月1日至1997年12月31日期间转诊至沙特阿拉伯东部省胡拜尔法赫德国王大学医院电诊断科的所有14至18岁患者的临床资料，包括发作的详细描述、检查、脑电图（EEG）和计算机断层扫描（CT）结果。数据录入标准数据库文件，并使用个人计算机进行分析。结果与同一研究期间从263名≤13岁儿童（72%）和73名>18岁成人（20%）中获得的两个先前的伴随数据集进行比较。

结果

研究了29例新诊断为复发性癫痫发作的患者（14例男性和15例女性，平均年龄15.7岁）。发现10.3%的患者有癫痫发作的阳性家族史。主要发作类型为部分性发作11例（37.9%）、部分性发作继发全面性发作6例（20.7%）和全面性发作12例（41.4%）。癫痫综合征类型包括局灶性相关性15例（51.7%）、全面性12例（41.4%）和未定型2例（16.9%）。脑电图异常21例（72.4%），有癫痫样放电，局灶性11例（52.4%），全面性9例（42.8%），非癫痫样放电1例（4.8%）。21例（72.4%）患者的头颅CT检查结果正常，8例（27.6%）患者异常，其中局灶性病变6例（75%），广泛性脑萎缩2例（25%）。在包括儿童和成人在内的365例研究对象中，新诊断为癫痫发作的青少年占8%。