Inserm U844, CHU Saint Eloi, INM, 80 rue Augustin Fliche, 34295 Montpellier cedex 5, France.
Clin Immunol. 2013 Jul;148(1):56-65. doi: 10.1016/j.clim.2013.03.010. Epub 2013 Mar 29.
Recently, various micro(mi)RNAs have been found deregulated in the setting of rheumatoid arthritis (RA), but their role in the pathogenesis of this disease remains a matter of debate. In the meanwhile, increasing evidence indicates a defective function of regulatory T cells (Tregs) in RA. This review discusses relevant studies addressing the function of Tregs and Cytotoxic T-Lymphocyte Antigen 4 in RA, provides recent data on the role of miRNAs for Tregs homeostasis, and focuses on the role of miR-155 in Tregs. In a final perspective section we discuss the potential impact of therapeutic miR-155 modulation in RA.
最近，人们发现各种 micro(mi)RNAs 在类风湿关节炎（RA）的发病机制中失调，但它们在这种疾病发病机制中的作用仍存在争议。同时，越来越多的证据表明 RA 患者调节性 T 细胞（Tregs）的功能缺陷。本综述讨论了与 Tregs 和细胞毒性 T 淋巴细胞抗原 4（Cytotoxic T-Lymphocyte Antigen 4，CTLA-4）在 RA 中的功能相关的研究，提供了关于 miRNA 对 Tregs 稳态作用的最新数据，并重点关注 miR-155 在 Tregs 中的作用。在最后的观点部分，我们讨论了治疗性 miR-155 调节在 RA 中的潜在影响。
