Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel.
Med Oncol. 2013;30(2):598. doi: 10.1007/s12032-013-0598-4. Epub 2013 May 7.
The current study compares FDG uptake in the ovaries and uterus before and after chemotherapy with regard to the menstrual cycle and patient's age. The FDG PET/CT studies of 182 women of reproductive age (12-50 years) referred for the assessment of various malignancies were evaluated. Patterns and degree of FDG uptake in the ovaries or uterus were correlated with patient's age, chemotherapy and with the phase of the menstrual cycle. Physiological FDG uptake in ovaries of women <35 years who did not receive chemotherapy occurred with two peaks: at the beginning of menstrual cycle and at mid-cycle around ovulation. After chemotherapy, women <35 years showed FDG ovarian uptake during various stages of the menstrual cycle. In women >35 years, there was no difference in FDG ovarian uptake before and after chemotherapy. There was a negative relationship between the time elapsed from end of chemotherapy to the incidence of uptake in the ovary (p < 0.001). Bilateral ovarian uptake was significantly more prevalent in women < 35 years after chemotherapy (p < 0.01), with a significant negative dependence to time from the end of chemotherapy (p < 0.05). There was no statistically significant difference in FDG uptake in the uterus before and after chemotherapy in both age groups, as well as in SUVmax measurements in the ovaries and uterus. Chemotherapy may affect physiological FDG uptake in reproductive organs of women of reproductive age.
本研究比较了化疗前后卵巢和子宫的 FDG 摄取情况，观察其与月经周期和患者年龄的相关性。对 182 例处于生育年龄（12-50 岁）的女性的 FDG PET/CT 检查结果进行了评估，这些女性因各种恶性肿瘤就诊。对卵巢或子宫的 FDG 摄取模式和程度与患者年龄、化疗以及月经周期阶段进行了相关性分析。未接受化疗的<35 岁女性，卵巢的生理性 FDG 摄取存在两个高峰：月经周期开始时和排卵时的中期。化疗后，<35 岁的女性在月经周期的各个阶段都出现卵巢 FDG 摄取。而>35 岁的女性，化疗前后卵巢 FDG 摄取无差异。从化疗结束到卵巢摄取发生的时间与 FDG 摄取之间存在负相关（p<0.001）。化疗后，<35 岁的女性双侧卵巢摄取更为常见（p<0.01），且与化疗结束时间之间存在显著的负相关（p<0.05）。两组年龄患者的子宫化疗前后 FDG 摄取以及卵巢和子宫的 SUVmax 测量值均无统计学差异。化疗可能会影响生育期女性生殖器官的生理性 FDG 摄取。
