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[抗高血压药物试验也揭示了肾脏保护作用]

[Antihypertensive drug trials also reveal renoprotective effects].

作者信息

Kiss István

机构信息

Szent Imre Oktató Kórház Nephrologia-Hypertonia Profil Budapest.

出版信息

Orv Hetil. 2013 May 12;154(19):753-6. doi: 10.1556/OH.2013.29609.

Abstract

The author analyzes the applicability of the renin-angiotensin system blocking drugs in patients with chronic kidney disease emphasizing their renoprotective (blood pressure and albuminuria lowering) and cardiovascular risk decreasing effects. As opposed to a previously-published statement, the author believes that their application is fundamental, particularly in combination with calcium-antagonist drugs. Relying on many references the author suggests that combined treatment with different renin-angiotensin system blocking drugs cannot be entirely ruled out, although it is not yet recommended.

摘要

作者分析了肾素-血管紧张素系统阻断药物在慢性肾病患者中的适用性,强调了它们的肾脏保护作用(降低血压和蛋白尿)以及降低心血管风险的作用。与之前发表的观点相反,作者认为这些药物的应用至关重要,尤其是与钙拮抗剂联合使用时。基于众多参考文献,作者表明,尽管目前尚不推荐,但不能完全排除不同肾素-血管紧张素系统阻断药物联合治疗的可能性。

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