最近在研究互变酶超家族中酶的混杂性方面取得了进展。
Recent advances in the study of enzyme promiscuity in the tautomerase superfamily.
机构信息
Department of Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
出版信息
Chembiochem. 2013 May 27;14(8):917-26. doi: 10.1002/cbic.201300098. Epub 2013 May 3.
PMID:23649962
Abstract
Catalytic promiscuity and evolution: Many enzymes exhibit catalytic promiscuity--the ability to catalyze reactions other than their biologically relevant one. These reactions can serve as starting points for both natural and laboratory evolution of new enzymatic functions. Recent advances in the study of enzyme promiscuity in the tautomerase superfamily are discussed.
摘要
催化多功能性与进化
许多酶表现出催化多功能性——即能够催化除其生物学相关反应之外的其他反应。这些反应可以作为自然和实验室进化新酶功能的起点。本文讨论了在互变异构酶超家族中对酶多功能性的研究进展。
Zotero 插件