具有按需药物释放能力的链式断裂聚合物治疗剂。
Chain-shattering polymeric therapeutics with on-demand drug-release capability.
机构信息
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL 61801, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6435-9. doi: 10.1002/anie.201300497. Epub 2013 May 6.
Abstract
We designed and synthesized trigger-responsive chain-shattering polymeric therapeutics (CSPTs) via condensation polymerization of a UV-or hydrogen peroxide-responsive domain and a bisfunctional drug as co-monomers. CSPTs have precisely controlled molecular composition and unique chain-shattering type of drug release mechanism. Drug release kinetics can be precisely controlled by means of the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive and antitumor efficacy.
摘要
我们通过将紫外线或过氧化物响应性结构域和双功能药物作为共聚单体进行缩合聚合，设计并合成了触发响应型链式断裂聚合物治疗剂（CSPTs）。CSPTs 具有精确控制的分子组成和独特的链式断裂型药物释放机制。通过触发处理可以精确控制药物释放动力学。含有化疗药物的 CSPTs 表现出触发响应和抗肿瘤功效。
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