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用于药物输送的生物响应性聚合物纳米颗粒。

Biologically responsive polymeric nanoparticles for drug delivery.

机构信息

Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston MA 02215, USA.

出版信息

Adv Mater. 2012 Jul 24;24(28):3878-86. doi: 10.1002/adma.201200420.

Abstract

Responsive nanoparticles that release their drug cargo in accordance with a change in pH or oxidative stress are of significant clinical interest as this approach offers the opportunity to link drug delivery to a specific location or disease state. This research news article reviews the current state of this field by examining a series of published articles that highlight the novelty and benefits of using responsive polymeric particles to achieve functionally-targeted drug delivery.

摘要

响应型纳米粒子能够根据 pH 值或氧化应激的变化释放其药物货物,这在临床上具有重要意义,因为这种方法为将药物递送到特定位置或疾病状态联系起来提供了机会。通过检查一系列突出使用响应性聚合物颗粒实现功能靶向药物递送的新颖性和益处的已发表文章,本研究新闻文章综述了该领域的现状。

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