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具有聚集诱导发射的氧化还原敏感聚合物胶束用于生物成像和抗癌药物递送。

Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs.

机构信息

Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.

Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China.

出版信息

J Nanobiotechnology. 2021 Jan 7;19(1):14. doi: 10.1186/s12951-020-00761-9.

DOI:10.1186/s12951-020-00761-9
PMID:33413405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7791786/
Abstract

BACKGROUND

Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject.

RESULTS

To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells.

CONCLUSIONS

A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

摘要

背景

纳米药物传递系统在癌症的有效治疗方面显示出巨大的应用前景。聚合物胶束作为靶向药物传递和控制药物释放的实用纳米载体，受到了广泛的关注，然而，胶束的分布和药物的释放很难在癌细胞中进行追踪。因此，构建一种用于智能释放抗癌药物以及同时进行诊断成像和治疗的氧化还原敏感多功能药物传递系统仍然是一个具有吸引力的研究课题。

结果

为了构建用于同时成像和癌症化疗的智能药物传递系统，制备了 mPEG-ss-Tripp 并自组装成具有 105nm 直径的氧化还原敏感聚合物胶束，基于聚集诱导发射，使用共聚焦激光扫描显微镜很容易在细胞内检测到这些胶束。当 GSH 还原二硫键时，载药胶束在细胞内迅速释放药物。载药胶束抑制了小鼠的肿瘤异种移植物，而没有 GSH 响应性二硫键时，这种疗效较低。这些结果建立了一种用于细胞内成像和氧化还原触发药物递送到癌细胞的创新多功能聚合物胶束。

结论

构建了一种具有 AIE 特性的新型氧化还原敏感药物传递系统，用于同时进行细胞成像和智能药物传递和释放。这种智能药物传递系统为多功能药物传递系统开辟了新的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/210de9d05670/12951_2020_761_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/0e00d8df3718/12951_2020_761_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/a2263f966f95/12951_2020_761_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/bdae99fd036a/12951_2020_761_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/b4b8d4550e4f/12951_2020_761_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/7cfff8d69168/12951_2020_761_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/ebb3fa7cad40/12951_2020_761_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/033f17c507d6/12951_2020_761_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/7a83d1960ab1/12951_2020_761_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/1f51cf2d7863/12951_2020_761_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/db3bc6f092b6/12951_2020_761_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/bb0cdb654893/12951_2020_761_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/210de9d05670/12951_2020_761_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/0e00d8df3718/12951_2020_761_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/a2263f966f95/12951_2020_761_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/bdae99fd036a/12951_2020_761_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/b4b8d4550e4f/12951_2020_761_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/7cfff8d69168/12951_2020_761_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/ebb3fa7cad40/12951_2020_761_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/033f17c507d6/12951_2020_761_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/7a83d1960ab1/12951_2020_761_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/1f51cf2d7863/12951_2020_761_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/db3bc6f092b6/12951_2020_761_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/bb0cdb654893/12951_2020_761_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e1/7791786/210de9d05670/12951_2020_761_Fig10_HTML.jpg

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本文引用的文献

1
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2
Dual cellular stimuli-responsive hydrogel nanocapsules for delivery of anticancer drugs.用于递送抗癌药物的双细胞刺激响应性水凝胶纳米胶囊
J Mater Chem B. 2016 Jul 28;4(28):4922-4933. doi: 10.1039/c6tb00651e. Epub 2016 Jul 4.
3
A pH-responsive AIE nanoprobe as a drug delivery system for bioimaging and cancer therapy.
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J Pharm Anal. 2025 Jan;15(1):101070. doi: 10.1016/j.jpha.2024.101070. Epub 2024 Aug 14.
4
Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review.用于抗癌药物递送的氧化还原操纵纳米载体：系统评价。
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5
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J Nanobiotechnology. 2024 Aug 21;22(1):502. doi: 10.1186/s12951-024-02754-4.
6
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7
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Curr Pharm Des. 2025;31(4):244-260. doi: 10.2174/0113816128304018240415095912.
8
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Cells. 2023 May 29;12(11):1497. doi: 10.3390/cells12111497.
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J Mater Chem B. 2015 Oct 7;3(37):7401-7407. doi: 10.1039/c5tb01169h. Epub 2015 Aug 25.
4
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5
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Biomater Sci. 2019 Jun 25;7(7):2803-2811. doi: 10.1039/c9bm00002j.
6
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Biomacromolecules. 2018 Dec 10;19(12):4658-4667. doi: 10.1021/acs.biomac.8b01423. Epub 2018 Nov 16.
8
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Bioconjug Chem. 2018 Dec 19;29(12):4050-4061. doi: 10.1021/acs.bioconjchem.8b00671. Epub 2018 Nov 29.
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