Gluskowski J, Hawrylkiewicz I, Zych D, Zieliński J
Dept of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Eur Respir J. 1990 Apr;3(4):403-7.
Effects of 12 months steroid treatment on pulmonary haemodynamics in 24 patients with pulmonary sarcoidosis, stage II and III, were investigated. All patients had a chest radiograph, lung function tests, and pulmonary haemodynamics (measured at rest and during submaximal exercise) prior to the treatment. Resting pulmonary hypertension was found in 3 patients. In 18 an abnormal increase in pulmonary arterial mean pressure (PAP) on exercise was observed. All investigations were repeated after a year of treatment. In almost all patients (22) a regression of radiological changes in the lungs and improvement of pulmonary function were observed. The changes in pulmonary circulation were less uniform. In only half of the patients studied was regression of the disease seen on chest X-ray and improvement in lung function accompanied by improvement in pulmonary haemodynamics.
研究了12个月的类固醇治疗对24例II期和III期肺结节病患者肺血流动力学的影响。所有患者在治疗前均进行了胸部X光检查、肺功能测试和肺血流动力学检查（静息和次极量运动时测量）。3例患者存在静息性肺动脉高压。18例患者在运动时观察到肺动脉平均压（PAP）异常升高。治疗一年后重复进行所有检查。几乎所有患者（22例）肺部的放射学改变均有消退，肺功能得到改善。肺循环的变化不太一致。在仅一半接受研究的患者中，胸部X光片上可见病情消退，肺功能改善并伴有肺血流动力学改善。
