氨茶碱和维拉帕米对犬膈肌力量产生的影响。

Effect of aminophylline and verapamil upon diaphragmatic force generation in dogs.

作者信息

De Vito E L, Roncoroni A J

机构信息

Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.

出版信息

Eur Respir J. 1990 Apr;3(4):456-62.

PMID:2365040

Abstract

The effects on the diaphragm of verapamil (VPM) and aminophylline (AMP) were studied in dogs during stimulation of phrenic nerves at the 5th cervical roots (5th-PS) or transvenously at the trunk (T-PS). Transdiaphragmatic pressure (Pdi)/frequency curves were constructed. Our findings were: 1) AMP increased Pdi at all stimulation frequencies (p less than 0.01) during 5th-PS but only at 10-30 Hz during T-PS; 2) in other dogs infusion of VPM (0.14 mg.kg-1.min-1) decreased Pdi at all frequencies (p less than 0.025) without change in diaphragmatic blood flow; 3) the effects of VPM were completely reverted by AMP; 4) after a large amount of AMP, infusion of VPM (0.21 mg.kg-1.min-1) decreased Pdi at all frequencies. Since these drugs have several mechanisms of action and do not show mutual blocking effect, different action sites are suggested.

摘要

在狗身上，通过刺激第5颈神经根（第5颈段膈神经）或在躯干静脉内刺激膈神经，研究了维拉帕米（VPM）和氨茶碱（AMP）对膈肌的影响。构建了跨膈压（Pdi）/频率曲线。我们的研究结果如下：1）在第5颈段膈神经刺激期间，氨茶碱在所有刺激频率下均增加Pdi（p<0.01），但在静脉内刺激膈神经期间仅在10 - 30Hz时增加；2）在其他狗中，输注维拉帕米（0.14mg·kg-1·min-1）在所有频率下均降低Pdi（p<0.025），而膈肌血流量无变化；3）氨茶碱可完全逆转维拉帕米的作用；4）在给予大量氨茶碱后，输注维拉帕米（0.21mg·kg-1·min-1）在所有频率下均降低Pdi。由于这些药物有多种作用机制且未显示出相互阻断作用，提示存在不同的作用位点。