胎牛血清乙酰胆碱酯酶的完整氨基酸序列及其在不同区域与其他胆碱酯酶的比较。
Complete amino acid sequence of fetal bovine serum acetylcholinesterase and its comparison in various regions with other cholinesterases.
作者信息
Doctor B P, Chapman T C, Christner C E, Deal C D, De La Hoz D M, Gentry M K, Ogert R A, Rush R S, Smyth K K, Wolfe A D
机构信息
Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
出版信息
FEBS Lett. 1990 Jun 18;266(1-2):123-7. doi: 10.1016/0014-5793(90)81522-p.
The complete amino acid sequence of a mammalian acetylcholinesterase from fetal bovine serum (FBS AChE) is presented. This enzyme has a high degree of sequence identity with other cholinesterases, liver carboxyesterases, esterase-6, lysophospholipase, and thyroglobulin. The locations of 191 amino acids in 10 regions of the FBS enzyme were compared with corresponding sequences of Torpedo, human, and Drosophila AChEs and human serum butyrylcholinesterase (BChE). In one region there is a marked difference in both the number of amino acids and their sequence between mammalian AChE and other AChEs and the human serum BChE. The amino acid sequence of FBS AChE showed overall homologies of 90% with human AChE, 60% with T. california AChE, 50% with human serum BChE, and 39% with Drosophila AChE in these regions.
本文给出了来自胎牛血清的哺乳动物乙酰胆碱酯酶（FBS AChE）的完整氨基酸序列。该酶与其他胆碱酯酶、肝脏羧酸酯酶、酯酶-6、溶血磷脂酶和甲状腺球蛋白具有高度的序列同一性。将FBS酶10个区域中的191个氨基酸位置与电鳐、人类和果蝇的乙酰胆碱酯酶（AChE）以及人类血清丁酰胆碱酯酶（BChE）的相应序列进行了比较。在一个区域中，哺乳动物AChE与其他AChE以及人类血清BChE在氨基酸数量及其序列上均存在显著差异。在这些区域中，FBS AChE的氨基酸序列与人类AChE的总体同源性为90%，与加州电鳐AChE的同源性为60%，与人类血清BChE的同源性为50%，与果蝇AChE的同源性为39%。
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