Burenkova O V, Aleksandrova E A, Zaraĭskaia I Iu
Ross Fiziol Zh Im I M Sechenova. 2013 Feb;99(2):212-20.
In the brain, histone acetylation underlies both learning and the maintenance of long-term sustained effects of early experience which is further epigenetically inherited. However, the role of acetylation in learning previously has only been studied in adult animals: high level of learning could be dependent on high levels of histone H3 acetylation in the brain. The role of acetylation in the mechanisms of early learning has not been studied. In the present work, we were interested whether histone deacetylase inhibitor sodium valproate which increases the level of histone H3 acetylation will affect early olfactory discrimination learning in 8-day-old pups of 129Sv mice that are characterized by low efficiency of learning with imitation of maternal grooming. Multiple valproate injections from 3rd to 6th postnatal day had a gender-dependent effect: learning was selectively improved in male but not in female pups. In the female pups, learning improvement was observed after multiple injections of saline. Possible epigenetic mechanisms underlying these sex differences are discussed.
在大脑中，组蛋白乙酰化是学习以及早期经历长期持续影响维持的基础，而这种影响会进一步通过表观遗传传递。然而，此前乙酰化在学习中的作用仅在成年动物中进行过研究：高水平的学习可能依赖于大脑中高水平的组蛋白H3乙酰化。乙酰化在早期学习机制中的作用尚未得到研究。在本研究中，我们感兴趣的是，增加组蛋白H3乙酰化水平的组蛋白去乙酰化酶抑制剂丙戊酸钠是否会影响129Sv小鼠8日龄幼崽的早期嗅觉辨别学习，这些幼崽在模仿母性梳理行为时学习效率较低。从出生后第3天到第6天多次注射丙戊酸钠具有性别依赖性效应：雄性幼崽的学习能力有选择性地提高，而雌性幼崽则没有。在雌性幼崽中，多次注射生理盐水后观察到学习能力有所改善。本文讨论了这些性别差异背后可能的表观遗传机制。
