Chen Wen-Ting, Fu Guo-Qiang, Shen Wei-Dong
Department of Anesthesiology, Shuguang Hospital, Shanghai University of Chinese Medicine, Shanghai 201203, China.
Zhen Ci Yan Jiu. 2013 Feb;38(1):83-7.
A large number of clinical trials and animal experiments have been carried out to focus on neurochemical mechanisms of acupuncture analgesia including postoperation pain relief, which may provide guidance for developing a novel clinical approach for postoperative analgesia. In the present paper, the authors review new progresses of researches on acupuncture analgesia for postoperative pain and side effects in the past few years from thyroidectomy, chest surgery, abdominal surgery, five sense organs (ear, nose, eye and throat) surgery, and others. Regarding the mechanism of acupuncture, central neurotransmitters (including the endop endorphin, 5-HT, gamma-aminobutyric acid, etc.), immune cytokines, cytokines from the spinal glia cells are complicated in the process of acupuncture analgesia. A lot of findings of researches demonstrated that acupuncture therapy is effective in reducing postoperative pain and adverse reactions as nausea, vomiting, etc. As a common technique widely used in the field of clinical medicine, the underlying mechanisms of acupuncture therapy for relieving post-surgery pain and side-effects should be studied profoundly in the future.
大量的临床试验和动物实验聚焦于针刺镇痛的神经化学机制,包括术后疼痛缓解,这可能为开发一种新的术后镇痛临床方法提供指导。在本文中,作者回顾了过去几年甲状腺切除术、胸外科手术、腹部手术、五官(耳、鼻、眼、喉)手术等术后疼痛及副作用的针刺镇痛研究新进展。关于针刺机制,中枢神经递质(包括内啡肽、5-羟色胺、γ-氨基丁酸等)、免疫细胞因子、脊髓胶质细胞产生的细胞因子在针刺镇痛过程中相互作用。大量研究结果表明,针刺疗法在减轻术后疼痛及恶心、呕吐等不良反应方面是有效的。作为临床医学领域广泛应用的一种常用技术,未来应深入研究针刺疗法缓解术后疼痛及副作用的潜在机制。