通过不对称溴内酯化反应拆分β-取代烯酸的动力学拆分。
Kinetic resolution of β-substituted olefinic carboxylic acids by asymmetric bromolactonization.
机构信息
Graduate School of Pharmaceutical Sciences, Osaka University , 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
出版信息
Org Lett. 2013 May 17;15(10):2526-9. doi: 10.1021/ol401007u. Epub 2013 May 7.
PMID:23650985
Abstract
A strategically novel kinetic resolution of β-substituted olefinic carboxylic acids is developed by asymmetric bromolactonization using an organocatalyst, 4-tBuPh-tris 1b. The cyclization stage, which provides δ-lactone, is proposed to be operative for discrimination of each enantiomer of carboxylic acids.
摘要
通过使用有机催化剂 4-tBuPh-tris 1b 进行不对称溴内酯化，开发了一种具有战略意义的新颖的β-取代烯属羧酸的动力学拆分方法。所提出的内酯化环化阶段对于羧酸的每个对映异构体的区分是有效的。
Zotero 插件