外源物代谢基因（EPHX1、NQO1 和 PON1）多态性与淋巴瘤易感性的关系：一项病例对照研究。
Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study.
机构信息
Pathology Department, Santa Lucía General University Hospital (HGUSL), 30202, Cartagena, Spain.
出版信息
BMC Cancer. 2013 May 7;13:228. doi: 10.1186/1471-2407-13-228.
BACKGROUND
The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens.
METHODS
We have studied the prevalence of three functional polymorphisms affecting these genes rs1051740 EPHX1, rs1800566 NQO1 and rs662 PON1 in 215 patients with lymphoma and 214 healthy controls.
RESULTS
Genotype frequencies for EPHX and NQO1 polymorphisms did not show any correlation with disease. In contrast, the GG genotype in the PON1 polymorphism was found to be strongly associated with the disease (15.3% vs. 4.7%; OR = 3.7 CI (95%): 1.8-7.7; p < 0.001). According to the pathological diagnosis this association was related to follicular (p = 0.004) and diffuse large B-cell (p = 0.016) lymphomas.
CONCLUSIONS
Despite the fact that further confirmation is needed, this study shows that the PON1 GG genotype in rs662 polymorphism could be a risk factor for B-cell lymphomas.
背景
遗传易感性和致癌暴露之间的相互作用在血液系统恶性肿瘤的发生中非常重要。EPHX1、NQO1 和 PON1 是三个编码直接参与潜在致癌物质解毒的蛋白质的基因。
方法
我们研究了影响这些基因的三个功能多态性（rs1051740 EPHX1、rs1800566 NQO1 和 rs662 PON1）在 215 例淋巴瘤患者和 214 例健康对照中的患病率。
结果
EPHX 和 NQO1 多态性的基因型频率与疾病无相关性。相反，PON1 多态性中的 GG 基因型与疾病强烈相关（15.3%对 4.7%；OR = 3.7 CI（95%）：1.8-7.7；p < 0.001）。根据病理诊断，这种关联与滤泡性（p = 0.004）和弥漫性大 B 细胞性（p = 0.016）淋巴瘤有关。
结论
尽管需要进一步确认，但本研究表明 rs662 多态性中的 PON1 GG 基因型可能是 B 细胞淋巴瘤的一个危险因素。
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