Pestiaux A, Ooghe P, Van Cauter J, Henry J P, Ligny G
Département Universitaire de Gastroentérologie, Université Libre de Bruxelles, Hôpital Civil de Charleroi, Belgique.
Gastroenterol Clin Biol. 1990;14(5):423-7.
Twenty-four intragastric acidity was measured by continuous recording using intragastric glass electrodes in 16 normal controls, 18 inactive duodenal ulcer patients and 7 patients with atrophic gastritis. Median pH for the 24 h period, for the 8 AM-8 PM period, and for the 8 PM-8 AM period were significantly lower in duodenal ulcer patients than in controls (1.19 vs 1.78; 1.17 vs 2.05; 1.27 vs 1.64). Median pH for these 3 periods were significantly higher in patients with atrophic gastritis than in controls (3.90; 3.72; 3.81). The median pH for the 24 h period was higher than the lower quartile value of the control group in 33 per cent of duodenal ulcer patients. During the night (24 h-3 h), duodenal ulcer patients had significantly lower median pH (1.03) than controls (1.51). Antisecretory treatment should be directed to decrease this period of unbuffered acidity.
使用胃内玻璃电极连续记录，测量了16名正常对照者、18名非活动性十二指肠溃疡患者和7名萎缩性胃炎患者的胃内酸度。十二指肠溃疡患者24小时时段、上午8点至晚上8点时段以及晚上8点至上午8点时段的pH中位数显著低于对照组（分别为1.19对1.78；1.17对2.05；1.27对1.64）。萎缩性胃炎患者这三个时段的pH中位数显著高于对照组（分别为3.90、3.72、3.81）。在33%的十二指肠溃疡患者中，24小时时段的pH中位数高于对照组的下四分位数。在夜间（24小时-3小时），十二指肠溃疡患者的pH中位数（1.03）显著低于对照组（1.51）。抗分泌治疗应旨在减少这段无缓冲酸度的时间。
