T 盒转录因子 Eomesodermin 对于小鼠胚胎中 AVE 的诱导是必不可少的。
The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.
机构信息
Developmental Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
出版信息
Genes Dev. 2013 May 1;27(9):997-1002. doi: 10.1101/gad.215152.113.
Abstract
Reciprocal inductive interactions between the embryonic and extraembryonic tissues establish the anterior-posterior (AP) axis of the early mouse embryo. The anterior visceral endoderm (AVE) signaling center emerges at the distal tip of the embryo at embryonic day 5.5 and translocates to the prospective anterior side of the embryo. The process of AVE induction and migration are poorly understood. Here we demonstrate that the T-box gene Eomesodermin (Eomes) plays an essential role in AVE recruitment, in part by directly activating the homeobox transcription factor Lhx1. Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity.
摘要
胚胎和胚胎外组织之间的相互诱导作用确立了早期小鼠胚胎的前后（AP）轴。前内脏内胚层（AVE）信号中心在胚胎第 5.5 天出现在胚胎的远端，并迁移到胚胎的前侧。AVE 诱导和迁移的过程还不太清楚。在这里，我们证明 T 盒基因 Eomesodermin (Eomes) 在 AVE 募集中发挥了重要作用，部分原因是直接激活同源盒转录因子 Lhx1。因此，Eomes 在内脏内胚层（VE）中的功能启动了一个指令性转录程序，控制 AP 身份。
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