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使用 4D CT、4D 应答器和门控带进行腹部和胰腺运动相关分析。

Abdominal and pancreatic motion correlation using 4D CT, 4D transponders, and a gating belt.

机构信息

Radiation Oncology, University of PennsylvaniaMedical Center, Philadelphia, PA 19104, USA.

出版信息

J Appl Clin Med Phys. 2013 May 6;14(3):4060. doi: 10.1120/jacmp.v14i3.4060.

Abstract

The correlation between the pancreatic and external abdominal motion due to respiration was investigated on two patients. These studies utilized four dimensional computer tomography (4D CT), a four dimensional (4D) electromagnetic transponder system, and a gating belt system. One 4D CT study was performed during simulation to quantify the pancreatic motion using computer tomography images at eight breathing phases. The motion under free breathing and breath-hold were analyzed for the 4D electromagnetic transponder system and the gating belt system during treatment. A linear curve was fitted for all data sets and correlation factors were evaluated between the 4D electromagnetic transponder system and the gating belt system data. The 4D CT study demonstrated a modest correlation between the external marker and the pancreatic motion with R-square values larger than 0.8 for the inferior-superior (inf-sup). Then, the relative pressure from the belt gating system correlated well with the 4D electromagnetic transponder system's motion in the anterior-posterior (ant-post) and the inf-post directions. These directions have a correlation value of -0.93 and 0.76, while the lateral only had a 0.03 correlation coefficient. Based on our limited study, external surrogates can be used as predictors of the pancreatic motion in the inf-sup and the ant-post directions. Although there is a low correlation on the lateral direction, its motion is significantly shorter. In conclusion, an appropriate treatment delivery can be used for pancreatic cancer when an internal tracking system, such as the 4D electromagnetic transponder system, is unavailable.

摘要

研究人员在两名患者身上研究了由于呼吸引起的胰腺和腹部外部运动之间的相关性。这些研究使用了四维计算机断层扫描(4D CT)、四维(4D)电磁转发器系统和门控带系统。在模拟过程中进行了一项 4D CT 研究,使用计算机断层扫描图像在八个呼吸阶段量化胰腺运动。在治疗过程中,分析了自由呼吸和屏气下 4D 电磁转发器系统和门控带系统的运动。对所有数据集拟合了线性曲线,并评估了 4D 电磁转发器系统和门控带系统数据之间的相关系数。4D CT 研究表明,外部标记与胰腺运动之间存在适度相关性,下-上(inf-sup)方向的 R 平方值大于 0.8。然后,带门控系统的相对压力与 4D 电磁转发器系统在前-后(ant-post)和后-下(inf-post)方向的运动很好地相关。这些方向的相关值分别为-0.93 和 0.76,而侧向仅具有 0.03 的相关系数。根据我们的有限研究,外部替代物可以用作 inf-sup 和 ant-post 方向胰腺运动的预测因子。尽管侧向的相关性较低,但它的运动明显更短。总之,当无法使用内部跟踪系统(如 4D 电磁转发器系统)时,可以使用适当的治疗方案来治疗胰腺癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1a7/5714426/137db6941355/ACM2-14-013-g001.jpg

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