Carreira M C, Crujeiras A B, Andrade S, Monteiro M P, Casanueva F F
CIBER de Fisiopatologia Obesidad y Nutricion CB06/03, Instituto Salud Carlos III, Complejo Hospitalario Universitario de Santiago CHUS, Santiago de Compostela, Spain.
Endocr Dev. 2013;25:49-58. doi: 10.1159/000346052. Epub 2013 Apr 25.
Growth hormone (GH) is secreted by the pituitary gland in a pulsatile manner. It is accepted that this pulsatility is primarily controlled by the hypothalamus, although this secretion can also be modulated by factors from GH-targeted organs, the pituitary and other regions of the central nervous systems, or by factors arriving from peripheral organs. In mammals, hypothalamic control of GH pulsatility is classically regulated by the interplay of two opposing hormones, stimulatory GHRH and inhibitory somatostatin (SS). Recognition of the gastric ghrelin peptide as the natural ligand for GH secretagogue receptor type 1a (GHS-R1a) added a new element to the complex physiological regulation of GH secretion and clarified some of its aspects that were previously not fully understood. In this review, we examine data that suggest that ghrelin may regulate GH secretion, as well as ghrelin's possible use as a therapeutic agent.
生长激素（GH）由垂体以脉冲方式分泌。尽管这种分泌也可受到来自生长激素作用靶器官、垂体、中枢神经系统其他区域的因素或外周器官传来的因素的调节，但人们普遍认为这种脉冲式分泌主要受下丘脑控制。在哺乳动物中，下丘脑对生长激素脉冲式分泌的控制传统上是由两种作用相反的激素，即刺激性的生长激素释放激素（GHRH）和抑制性的生长抑素（SS）相互作用来调节的。胃促生长素肽被确认为生长激素促分泌素受体1a型（GHS-R1a）的天然配体，这为生长激素分泌的复杂生理调节增添了新的元素，并阐明了其一些以前未被充分理解的方面。在本综述中，我们研究了表明胃促生长素可能调节生长激素分泌的数据，以及胃促生长素作为治疗药物的潜在用途。
