Gold Michael H, Kircik Leon H, Bucay Vivian W, Kiripolsky Monika G, Biron Julie A
Tennessee Clinical Research Center, Nashville, TN, USA.
J Drugs Dermatol. 2013 May;12(5):533-40.
Photoaged skin is characterized by a variety of clinical, histologic, and biochemical features.
To determine the efficacy of a new topical formulation of 1% retinol and the effects of this same formulation using a 0.5% retinol concentration to minimize irritation.
Patients at 2 sites (n=6, n=5) with photodamaged skin applied a novel suspension of retinol (1%) daily to their faces for 8 to 12 weeks. Clinicians graded improvement in ultraviolet-induced features at 4 to 6 weeks and at 8 to 12 weeks. Positive results of the observational pilot study warranted a follow-up study on the low concentration. At a third site, females (n=30) with facial photodamage applied the same formulation with or without retinol (0.5%) daily for 8 weeks. Twenty-two subjects applied the test product and 8 applied vehicle according to a randomized, double-blinded, institutional review board-approved protocol. Improvements in photodamage features were graded at 4 and 8 weeks.
In the observational pilot study, most participants showed improvement in overall photodamage, crow's feet, elasticity,wrinkles, brightness, and hyperpigmentation at 60 to 80 days. Improvements at 60 to 80 days were greater than at 30 to 46 days. In the low-concentration study with 0.5% retinol, improvements were modest, most likely due to the lower retinol concentration. Burning, pruritus, dryness, and erythema were minimal with the 0.5% retinol concentration.
The topical formulation of 1% retinol improves photodamaged skin for at least 8 to 12 weeks. Although improvements with the 0.5% retinol were more modest, side effects such as burning, dryness, pruritus, and erythema during the 8-week study period were minimal. These encouraging results justify a longer-term study to determine whether topically applied 0.5% retinol can provide benefits comparable with those seen with topically applied 1% retinol.
光老化皮肤具有多种临床、组织学和生化特征。
确定1%视黄醇新外用制剂的疗效，以及使用0.5%视黄醇浓度的同一制剂以尽量减少刺激的效果。
两个地点的患者（分别为n = 6和n = 5），皮肤有光损伤，每天在面部涂抹新型视黄醇悬浮液（1%），持续8至12周。临床医生在4至6周以及8至12周时对紫外线引起的特征改善情况进行分级。观察性初步研究的阳性结果促使对低浓度制剂进行后续研究。在第三个地点，面部有光损伤的女性（n = 30），每天涂抹含或不含视黄醇（0.5%）的同一制剂，持续8周。22名受试者根据随机、双盲、机构审查委员会批准的方案使用测试产品，8名受试者使用赋形剂。在4周和8周时对视损伤特征的改善情况进行分级。
在观察性初步研究中，大多数参与者在60至80天时，整体光损伤、鱼尾纹、弹性、皱纹、亮度和色素沉着均有改善。60至80天的改善大于30至46天。在0.5%视黄醇的低浓度研究中，改善程度较小，很可能是由于视黄醇浓度较低。0.5%视黄醇浓度时，灼烧感、瘙痒、干燥和红斑均很轻微。
1%视黄醇外用制剂可改善光损伤皮肤至少8至12周。虽然0.5%视黄醇的改善较轻微，但在8周研究期间，如灼烧感、干燥、瘙痒和红斑等副作用很轻微。这些令人鼓舞的结果证明有必要进行一项长期研究，以确定局部应用0.5%视黄醇是否能提供与局部应用1%视黄醇相当的益处。
