1Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th St., Bloomington, IN 47405, USA.
Psychol Sci. 2013 Jul 1;24(7):1309-16. doi: 10.1177/0956797612468010. Epub 2013 May 7.
Although preconception and prenatal maternal stress are associated with adverse outcomes in birth and childhood, their relation to infant mortality remains uncertain. We used logistic regression to study infant mortality risk following maternal stress within a population-based sample of infants born in Sweden between 1973 and 2008 (N = 3,055,361). Preconception (6-0 months before conception) and prenatal (between conception and birth) stress were defined as death of a first-degree relative of the mother. A total of 20,651 offspring were exposed to preconception stress, 26,731 offspring were exposed to prenatal stress, and 8,398 cases of infant mortality were identified. Preconception stress increased the risk of infant mortality independently of measured covariates, and this association was timing specific and robust across low-risk groups. Prenatal stress did not increase risk of infant mortality. These results suggest that the period immediately before conception may be a sensitive developmental period with ramifications for infant mortality risk.
虽然孕前和产前母体压力与出生和儿童时期的不良后果有关，但它们与婴儿死亡率的关系仍不确定。我们使用逻辑回归分析了 1973 年至 2008 年在瑞典出生的基于人群的婴儿样本（N=3055361）中母体压力对婴儿死亡率的风险。孕前（受孕前 6-0 个月）和产前（受孕至出生期间）压力定义为母亲的一级亲属死亡。共有 20651 名后代暴露于孕前压力，26731 名后代暴露于产前压力，确定了 8398 例婴儿死亡。孕前压力增加了婴儿死亡率的风险，这与测量的协变量无关，这种关联具有时间特异性，在低风险组中具有稳健性。产前压力不会增加婴儿死亡率的风险。这些结果表明，受孕前的时期可能是一个敏感的发育时期，对婴儿死亡率风险有影响。
