Wang C, Jiang Y, Xiao H, Xu P, Xiao S, Liao Y, He L
Hua Xi Yi Ke Da Xue Xue Bao. 1990 Mar;21(1):42-5.
Experimental results of anticancer activity of DHAQ.HCl are reported in this paper. It was discovered that DHAQ.HCl, mitoxantrone hydrochloride, had an obvious anticancer effect on the experimental tumor strains:Ehrlich ascites cancer, Sarcoma-180, Leukemia P388, etc., and that it was more effective to Leukemia P388 than to other strains. The anticancer activity of DHAQ.HCl was better than DHAQ (P less than 0.05). No side effect was observed on the local sites (s.c.) of tumor planted or drug injected. And also a good anticancer effect was observed on the sites of tumor planted by local injection. It is suggested that this observation can provide some information on the choice of routes of administration of this drug clinically.
本文报道了盐酸二氢阿霉素（DHAQ.HCl）抗癌活性的实验结果。发现盐酸二氢阿霉素，即米托蒽醌盐酸盐，对实验肿瘤株：艾氏腹水癌、肉瘤-180、白血病P388等有明显的抗癌作用，且对白血病P388的效果比对其他株系更显著。盐酸二氢阿霉素的抗癌活性优于二氢阿霉素（P<0.05）。在接种肿瘤或注射药物的局部部位（皮下）未观察到副作用。并且在局部注射接种肿瘤的部位也观察到了良好的抗癌效果。提示该观察结果可为该药物临床给药途径的选择提供一些信息。
