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二价铜与葡聚糖3-巯基-2-羟丙基醚(C-79)复合物的抑癌特性

Oncostatic properties of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79).

作者信息

Wieczorek Z, Giełdanowski J, Hraba T, Zimecki M, Mioduszewski J Z

出版信息

Arch Immunol Ther Exp (Warsz). 1983;31(5):707-13.

PMID:6202276
Abstract

The oncostatic properties of C-79 preparation were examined on the mice with: sarcoma Sa-180, melanoma B-16, Ehrlich carcinoma and leukemia P-388. The preparation was observed to prolong the life of animals with sarcoma Sa-180 and to modulate the morphology of tumors in them. The preparation had no effect on three remaining investigation models. The investigations carried out on mice of AKR strain have revealed that C-79 significantly suppresses the occurrence of spontaneous leukemia, prolonging the mouse survival-time.

摘要

在患有肉瘤 Sa - 180、黑色素瘤 B - 16、艾氏癌和白血病 P - 388 的小鼠身上检测了 C - 79 制剂的抑癌特性。观察到该制剂可延长患有肉瘤 Sa - 180 的动物的寿命,并调节其中肿瘤的形态。该制剂对其余三种研究模型没有影响。在 AKR 品系小鼠身上进行的研究表明,C - 79 可显著抑制自发性白血病的发生,延长小鼠存活时间。

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