Horne S L, Cockcroft D W, Dosman J A
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
Hum Hered. 1990;40(3):173-6. doi: 10.1159/000153926.
The frequencies of GC phenotypes in 104 patients with chronic obstructive airways disease (COAD) were compared with those in 413 control subjects. The distributions were significantly different with fewer patients with the GC 2 allele than expected (relative risks = 0.8, 0.7 and 0.5 for 2-2, 2-1S and 2-1F, respectively) and more 1F-1F patients than expected (relative risk = 4.8). These data suggest that the GC 2 allele exerts a protective effect, whereas 1F, when homozygous, increases the risk of developing COAD.
将104例慢性阻塞性气道疾病（COAD）患者的GC表型频率与413名对照者的频率进行了比较。分布存在显著差异，GC 2等位基因的患者比预期少（2-2、2-1S和2-1F的相对风险分别为0.8、0.7和0.5），而1F-1F患者比预期多（相对风险=4.8）。这些数据表明，GC 2等位基因具有保护作用，而1F纯合时会增加患COAD的风险。
