Division of Allergy and Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
J Investig Allergol Clin Immunol. 2013;23(1):43-9.
Latex allergy is an important cause of occupational allergy. In many countries the prevalence of latex allergy is still high and the profile of latex sensitization is unknown.
To evaluate the frequency of sensitization and allergy to latex in children and adolescents with myelomeningocele and to identify associated risk factors.
The study included 55 children and adolescents with myelomeningocele followed at a specialized center. In addition to a standard questionnaire and skin prick tests (SPTs) to aeroallergens and total latex, the patients underwent determination of total and specific serum IgE to latex and recombinant allergens.
We observed a prevalence of 25% for latex sensitization and of 20% for latex allergy. Twenty-four patients (43.6%) were atopic and the average age for the first reaction to latex was 44.5 months. Cutaneous reactions were the most frequently reported reactions (72.7%). Specific immunoglobulin (Ig) E to rHev b 1, rHev b 3, rHev b 5, rHev b 6.1, and rHev b 6.2 was detected in over 50% of patients allergic to latex. Multivariate analysis showed current asthma, atopy, and having undergone 4 or more operations to be risk factors for latex sensitization.
Our study documented a high prevalence of sensitization and allergy to latex in patients with myelomeningocele. Specific IgE to rHev b 1, rHev b 3, rHev b 5, rHev b 6.1, and rHev b 6.2 was detected in over 50% of children and adolescents with myelomeningocele who are allergic to latex. A history of current asthma, atopy, and having undergone 4 or more operations were independent risk factors for latex allergy.
乳胶过敏是职业性过敏的一个重要原因。在许多国家，乳胶过敏的患病率仍然很高，乳胶致敏的情况尚不清楚。
评估伴有脊膜脊髓膨出的儿童和青少年乳胶致敏和过敏的频率，并确定相关的危险因素。
该研究纳入了在一个专门中心接受治疗的 55 例伴有脊膜脊髓膨出的儿童和青少年。除了标准问卷和对气传过敏原和总乳胶的皮肤点刺试验（SPT）外，患者还进行了总和特异性血清 IgE 对乳胶和重组过敏原的测定。
我们观察到乳胶致敏的患病率为 25%，乳胶过敏的患病率为 20%。24 例患者（43.6%）为特应性，首次对乳胶产生反应的平均年龄为 44.5 个月。皮肤反应是最常报告的反应（72.7%）。对 rHev b 1、rHev b 3、rHev b 5、rHev b 6.1 和 rHev b 6.2 的特异性免疫球蛋白（Ig）E 在超过 50%对乳胶过敏的患者中被检测到。多变量分析显示，目前患有哮喘、特应性和接受过 4 次或以上手术是乳胶致敏的危险因素。
我们的研究记录了伴有脊膜脊髓膨出的患者乳胶致敏和过敏的高患病率。对 rHev b 1、rHev b 3、rHev b 5、rHev b 6.1 和 rHev b 6.2 的特异性 IgE 在超过 50%对乳胶过敏的伴有脊膜脊髓膨出的儿童和青少年中被检测到。目前患有哮喘、特应性和接受过 4 次或以上手术是乳胶过敏的独立危险因素。
