Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
J Investig Allergol Clin Immunol. 2013;23(2):89-93.
Atopic dermatitis (AD) is a chronic skin disorder of unknown origin that usually manifests for the first time in early infancy. Different types of genetic predisposition and environmental factors seem to be associated with the disease.
This study was performed to evaluate the frequency of alleles, genotypes, and haplotypes of interleukin (IL) 6 single-nucleotide polymorphisms (SNPs) at positions -174 and nt565 in 89 Iranian children with AD and 139 healthy controls.
The G allele was significantly more frequent at position -174 in IL6 in atopic patients than in the healthy controls (P < .001; OR, 2.82). Genotype GG was found at the same position in 71% of the patients; this frequency was significantly higher than the frequency of 30% recorded in the controls (P < .001; OR, 5.60). The GG haplotype of IL6 (-174, nt565) was significantly more frequent in the atopic patients than in the healthy controls (P < .001; OR, 2.99).
A significant increase in the frequency of the G allele and GG genotype at position -174 of IL6 was found in patients with AD, thus suggesting that production of this cytokine is greater in atopic patients.
特应性皮炎（AD）是一种病因不明的慢性皮肤疾病，通常在婴儿早期首次出现。不同类型的遗传易感性和环境因素似乎与该疾病有关。
本研究旨在评估 89 名伊朗 AD 患儿和 139 名健康对照者白细胞介素（IL）6 单核苷酸多态性（SNP）在位置-174 和 nt565 的等位基因、基因型和单倍型的频率。
在 IL6 的位置-174 处，特应性患者的 G 等位基因明显比健康对照组更频繁（P <.001；OR，2.82）。在同一位置发现基因型 GG 在 71%的患者中存在；这一频率明显高于对照组 30%的记录（P <.001；OR，5.60）。IL6（-174，nt565）的 GG 单倍型在特应性患者中明显比健康对照组更频繁（P <.001；OR，2.99）。
在 AD 患者中发现 IL6 位置-174 的 G 等位基因和 GG 基因型的频率显著增加，这表明这种细胞因子在特应性患者中的产生量更大。
