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Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches.

作者信息

Bass Phillip D, Gubler Daniel A, Judd Ted C, Williams Robert M

机构信息

Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States.

出版信息

Chem Rev. 2013 Aug 14;113(8):6816-63. doi: 10.1021/cr3001059. Epub 2013 May 8.

Abstract
摘要

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本文引用的文献

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Mitomycin C inhibits ribosomal RNA: a novel cytotoxic mechanism for bioreductive drugs.
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Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways.
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Analysis of a parallel branch in the mitomycin biosynthetic pathway involving the mitN-encoded aziridine N-methyltransferase.
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