Szent-Györgyi A, McLaughlin J A
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1610-1. doi: 10.1073/pnas.72.4.1610.
Glyoxal and methylglyoxal interact with biogenic amines and form biologically active free radicals. Electron spin resonance absorption of the radical at room temperature is characterized by a signal at g equals 2.004 with peak-to-peak width of 29 G. An optical absorption at 400 nm with molar absorptivity of 23,000 accompanies the formation of the radical. The dry powdered preparation of the same reaction, which is considered to be the seconardy product, gives an electron spin resonance signal much narrower and 1/200 in intensity compared with the one in solution. Similarly the 400 nm absorption intensity is 1/8 that of the primary product. Possible biological significance of the primary and the secondary product, in relation to muscular dystrophy and photophosphorylation, is discussed.
乙二醛和甲基乙二醛与生物胺相互作用并形成生物活性自由基。室温下该自由基的电子自旋共振吸收特征是在g等于2.004处有一个信号，峰-峰宽度为29 G。该自由基的形成伴随着在400 nm处的光吸收，摩尔吸光系数为23,000。同一反应的干燥粉末制剂被认为是二级产物，与溶液中的相比，其电子自旋共振信号窄得多，强度为溶液中信号的1/200。同样，400 nm处的吸收强度是初级产物的1/8。讨论了初级和二级产物与肌肉营养不良和光合磷酸化相关的可能生物学意义。
