Cedars Sinai Medical Center, 8635 W, 3rd Street 160W, Los Angeles, CA 90048, USA.
Gynecol Endocrinol. 2013 Jun;29(6):615-8. doi: 10.3109/09513590.2013.788638.
Menstrual irregularity has been associated with insulin resistance, type 2 diabetes mellitus and markers of metabolic dysfunction. This study aimed to determine whether irregular menstrual cycles (MCs) in reproductive-age women are associated with the weight of their daughters at birth and growth up to age five. We studied 4863 pregnant women with menstrual history data in a prospective cohort, recruited from the Kaiser Health Plan (1959-1966). Serial measures of their daughters' weight and height were abstracted from medical records. We used analysis of covariance, stratified by maternal body mass index, to explore the association between maternal MC and infant birth weight (BW). We included 4774 daughters in a repeated measures analysis to compare the effect of maternal MC on childhood weight through age five. Daughters of non-obese women with irregular MC had a statistically significant lower BW compared to daughters of women with regular MC; this difference was notably amplified among obese women. The daughters' weights were not statistically different when growth was assessed from birth to five years. We conclude that daughters of obese women with irregular MC, in particular, had significantly lower BW compared to daughters of women with regular MC, which did not persist over five years of follow-up.
月经不规律与胰岛素抵抗、2 型糖尿病和代谢功能障碍的标志物有关。本研究旨在确定生育年龄妇女的不规律月经周期（MC）是否与女儿的出生体重和五岁前的生长有关。我们研究了来自 Kaiser Health Plan（1959-1966）的前瞻性队列中 4863 名有月经史数据的孕妇。从医疗记录中提取了她们女儿体重和身高的系列测量值。我们使用协方差分析，按母体体重指数分层，探讨了母体 MC 与婴儿出生体重（BW）之间的关系。我们纳入了 4774 名女儿进行重复测量分析，以比较母体 MC 对五岁以下儿童体重的影响。与月经规律的妇女相比，非肥胖妇女月经不规律的女儿的 BW 有统计学意义的降低；这种差异在肥胖妇女中尤为明显。从出生到五岁评估生长时，女儿的体重没有统计学差异。我们的结论是，与月经规律的妇女相比，特别是肥胖妇女月经不规律的女儿 BW 显著降低，且这种情况在五年的随访中并未持续。
