Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Am J Clin Nutr. 2013 Jul;98(1):174-9. doi: 10.3945/ajcn.112.054734. Epub 2013 May 8.
Vitamin D deficiency is an important health issue, particularly among people residing in northern countries. Low concentrations of 25-hydroxyvitamin D [25(OH)D] have been linked to several health conditions.
The objective was to determine the association between plasma 25(OH)D and pulmonary function and the effect modifications of sex and body mass index (BMI) in adults.
A cross-sectional study included 3359 adults aged ≥18 y who participated in the Canadian Health Measures Survey, and a 2-stage multiple linear regression analysis was conducted.
Overall, 26% of the adults had a plasma 25(OH)D concentration <50 nmol/L, which is considered deficient (ie, hypovitaminosis D). This deficiency was more prevalent among men than among women (30% compared with 23%). Regression analysis showed that deficient plasma 25(OH)D was associated with lower mean residual forced vital capacity and forced expiratory volume in 1 s in men after adjustment for covariates. When further stratified by BMI, the associations were more marked in overweight and obese men. Vitamin D deficiency associated with pulmonary function was not statistically significant in normal-weight men or in women, regardless of BMI categories. Similar results were obtained when plasma 25(OH)D was examined as a continuous variable in the models.
Hypovitaminosis D may be a risk factor for lung dysfunction, especially for overweight and obese men. Further research is necessary to determine the mechanism of the interrelation between vitamin D, adiposity, and pulmonary function.
维生素 D 缺乏是一个重要的健康问题，尤其在居住在北方国家的人群中。低浓度的 25-羟维生素 D [25(OH)D]与多种健康状况有关。
本研究旨在确定成年人血浆 25(OH)D 与肺功能之间的关系，并探讨性别和体重指数 (BMI) 的修饰作用。
本研究为一项横断面研究，共纳入 3359 名年龄≥18 岁的成年人，他们参加了加拿大健康测量调查，并进行了两阶段多元线性回归分析。
总体而言，26%的成年人血浆 25(OH)D 浓度<50 nmol/L，这被认为是缺乏的（即维生素 D 不足）。这种缺乏在男性中比在女性中更为普遍（30%比 23%）。回归分析显示，在调整了协变量后，男性中血浆 25(OH)D 缺乏与平均残馀用力肺活量和 1 秒用力呼气量较低相关。当按 BMI 进一步分层时，超重和肥胖男性的相关性更为显著。无论 BMI 类别如何，在正常体重男性或女性中，维生素 D 缺乏与肺功能之间的关联均无统计学意义。在模型中，当将血浆 25(OH)D 作为连续变量进行检查时，也得到了类似的结果。
维生素 D 不足可能是肺功能障碍的一个危险因素，尤其是超重和肥胖的男性。需要进一步研究以确定维生素 D、肥胖和肺功能之间相互关系的机制。
