Chan Lingtak-Neander, Neilson Charlotte H, Kirk Elizabeth A, Colovos Tiana F, Javelli Diane R, Khandelwal Saurabh
Department of Pharmacy, School of Pharmacy, University of Washington, 1959 NE Pacific Street, Box 357630, Seattle, WA, 98195, USA.
Graduate Program in Nutritional Sciences, School of Public Health, Seattle, WA, USA.
Obes Surg. 2015 Dec;25(12):2321-7. doi: 10.1007/s11695-015-1685-8.
Patients who undergo bariatric surgery are at risk for micronutrient deficiencies. The aims of this study were to determine the prevalence and predictors of vitamin D deficiency in obese patients residing in the northern climate, and to evaluate the effectiveness of a daily maintenance dose of vitamin D 2000 IU in preventing hypovitaminosis D within 1 year after bariatric surgery.
A cohort study involving adult patients undergoing RYGB was conducted. Longitudinal changes in serum vitamin D concentrations and clinical parameters were measured and collected.
Data from 134 recipients of RYGB were analyzed. Hypovitaminosis D was identified in 86 patients (64 %), and was significantly affected by seasonal change and the number of comorbidities. Follow-up data were available in 60 patients. Vitamin D sufficiency was achieved in 62.5 % of those patients with baseline vitamin D insufficiency. A dose-response relationship of vitamin D intake was observed, with the most significant increase in 25(OH)D associated with daily vitamin D intakes ≥ 2000 IU.
The prevalence of hypovitaminosis D before RYGB was comparable to patients living in the non-northern climate. Daily vitamin D intake meeting at least 2000 IU is associated with greater improvement in serum vitamin D concentration.
接受减肥手术的患者存在微量营养素缺乏的风险。本研究的目的是确定居住在北方气候地区的肥胖患者维生素D缺乏的患病率和预测因素，并评估减肥手术后1年内每日维持剂量2000 IU维生素D预防维生素D缺乏症的有效性。
进行了一项涉及接受Roux-en-Y胃旁路术（RYGB）的成年患者的队列研究。测量并收集血清维生素D浓度和临床参数的纵向变化。
分析了134例接受RYGB患者的数据。86例患者（64%）被诊断为维生素D缺乏症，且受季节变化和合并症数量的显著影响。60例患者有随访数据。基线维生素D不足的患者中，62.5%实现了维生素D充足。观察到维生素D摄入量的剂量反应关系，每日维生素D摄入量≥2000 IU时，25(OH)D的增加最为显著。
RYGB术前维生素D缺乏症的患病率与非北方气候地区的患者相当。每日维生素D摄入量至少达到2000 IU与血清维生素D浓度的更大改善相关。
