Hahn C H, Stangerup S E, Caye-Thomasen P
Department of Oto-rhino-laryngology, Head and Neck Surgery, University Hospital Rigshospitalet, Copenhagen, Denmark.
J Laryngol Otol. 2013 Jun;127(6):568-73. doi: 10.1017/S0022215113000844. Epub 2013 May 9.
To evaluate residual tumour occurrence after vestibular schwannoma surgery, based on intra-operative registration and magnetic resonance imaging one year post-operatively.
Patients undergoing translabyrinthine surgery for vestibular schwannoma in Denmark between 1976 and 2008 were registered in a national database covering 5.5 million inhabitants.
Translabyrinthine surgery was undertaken on 1143 patients. Of these, 978 had total, 140 near-total and 25 subtotal tumour excision, as assessed intra-operatively by the surgeon. One year after surgery, 65 per cent of small tumour remnants and 11 per cent of large tumour remnants were not visible on magnetic resonance imaging. The mean pre-operative size was significantly smaller for totally excised tumours, compared with near-totally and subtotally excised tumours. Revision surgery was performed for 14 patients (1.2 per cent), of whom 2 had received total, 5 near-total and 6 subtotal excisions initially.
Most residual tumours disappear spontaneously, probably due to devascularisation. Few patients with a small residual vestibular schwannoma will require revision surgery or secondary radiotherapy.
基于术中配准及术后一年的磁共振成像,评估前庭神经鞘瘤手术后残留肿瘤的发生情况。
1976年至2008年间在丹麦接受经迷路前庭神经鞘瘤手术的患者被登记在一个覆盖550万居民的国家数据库中。
1143例患者接受了经迷路手术。其中,术中外科医生评估978例肿瘤完全切除,140例接近完全切除,25例次全切除。术后一年,磁共振成像显示65%的小肿瘤残余和11%的大肿瘤残余不可见。与接近完全切除和次全切除的肿瘤相比,完全切除肿瘤的术前平均大小明显更小。14例患者(1.2%)接受了翻修手术,其中2例最初接受了完全切除,5例接近完全切除,6例次全切除。
大多数残留肿瘤可能因血运阻断而自行消失。少数残留小前庭神经鞘瘤的患者需要翻修手术或二次放疗。