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孤立性三尖瓣心内膜炎的外科治疗-单中心长期随访。

Surgical treatment for isolated tricuspid valve endocarditis- long-term follow-up at a single institution.

机构信息

Department of Cardiac-, Thoracic-, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

出版信息

Circ J. 2013;77(8):2032-7. doi: 10.1253/circj.cj-12-1364. Epub 2013 May 9.

Abstract

BACKGROUND

Systematic long-term data on tricuspid valve (TV) endocarditis are limited. The aim of this study was to investigate the outcome of surgery for isolated TV endocarditis.

METHODS AND RESULTS

A total of 637 patients who underwent TV surgery between June 1996 and September 2012 at Hannover Medical School were retrospectively investigated. Of the 637 patients, 33 (14 female, mean age, 49 ± 21 years) underwent isolated TV surgery for endocarditis: biological TV replacement, n=14; mechanical TV replacement, n=4; TV reconstruction, n=15. A total of 28 cases were associated with i.v. drug abuse (n=14) or pacemaker infection (n=14). Staphylococcus (S.) aureus was the most common microorganism detected on preoperative blood culture. Mean follow-up was 6.0 ± 4.1 years (83% completed). Three patients (9%) died during the first 30 postoperative days. Survival at 1, 5 and 10 years was 88%, 73%, and 73%, respectively. Freedom from reoperation was 100%, 95%, and 88%, respectively. During follow-up New York Heart Association class improved significantly, and echocardiography identified remaining TV insufficiency grade ≥ II° only in 2 patients. Statistical analysis identified advanced age, logistic EuroSCORE and positive blood culture for S. aureus as significant risk factors for long-term mortality.

CONCLUSIONS

Isolated TV endocarditis is strongly associated with i.v. drug abuse or pacemaker infection. Long-term outcome is acceptable, independent of the surgical procedure.

摘要

背景

关于三尖瓣(TV)心内膜炎的系统长期数据有限。本研究旨在探讨单纯 TV 心内膜炎手术的结果。

方法和结果

回顾性调查了 1996 年 6 月至 2012 年 9 月在汉诺威医学院接受 TV 手术的 637 例患者。在 637 例患者中,33 例(14 例女性,平均年龄 49 ± 21 岁)因心内膜炎行单纯 TV 手术:生物 TV 置换 14 例;机械 TV 置换 4 例;TV 重建 15 例。共有 28 例与静脉内药物滥用(n=14)或起搏器感染(n=14)相关。术前血培养最常见的微生物是金黄色葡萄球菌(S. aureus)。平均随访时间为 6.0 ± 4.1 年(83%完成)。术后 30 天内有 3 例(9%)患者死亡。1、5 和 10 年的生存率分别为 88%、73%和 73%。无再手术率分别为 100%、95%和 88%。随访期间纽约心脏协会心功能分级显著改善,超声心动图仅发现 2 例患者存在残余 TV 功能不全≥Ⅱ级。统计分析发现,高龄、逻辑 EuroSCORE 和金黄色葡萄球菌血培养阳性是长期死亡的显著危险因素。

结论

单纯 TV 心内膜炎与静脉内药物滥用或起搏器感染密切相关。手术治疗的长期效果是可以接受的,与手术方式无关。

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