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孤立性三尖瓣心内膜炎患者的三尖瓣手术:围手术期参数及长期预后分析

Tricuspid Valve Surgery in Patients with Isolated Tricuspid Valve Endocarditis: Analysis of Perioperative Parameters and Long-Term Outcomes.

作者信息

Pfannmueller Bettina, Kahmann Mareike, Davierwala Piroze, Misfeld Martin, Bakhtiary Farhad, Binner Christian, Etz Christian, Mohr Friedrich Wilhelm

机构信息

Department of Heart Surgery, Leipzig Heart Centre, University of Leipzig, Leipzig, Germany.

出版信息

Thorac Cardiovasc Surg. 2017 Dec;65(8):626-633. doi: 10.1055/s-0035-1564926. Epub 2015 Oct 26.

Abstract

The aim of this study was to evaluate the perioperative characteristics and the short- and mid-term outcomes in patients undergoing tricuspid valve (TV) surgery for isolated TV endocarditis.  A total of 56 patients with isolated TV endocarditis underwent TV surgery at a single center between June 1995 and February 2012. Mean age of patients was 53.8 ± 17.1 years, 39 (69.6%) being male. The mean left ventricular ejection fraction was 60.4 ± 13.6% and 13 (23.2%) patients had diabetes mellitus. Average logistic EuroSCORE was 19.4 ± 17.0%. Mean follow-up was 4.7 ± 3.8 years.  Microbiological investigations revealed positive blood cultures in 89.1% of patients and positive intraoperative swabs in 51.9%. The most common pathogen (42.9%) isolated was , followed by coagulase-negative staphylococcus (17.9%).  A history of intravenous drug abuse (IVDA) was recorded in 11 patients (19.6%), of which 8 patients additionally had hepatitis C. A total of 15 patients (26.8%) had a permanent pacemaker/implantable cardioverter-defibrillator in situ. TV replacement was performed in 22 patients (39.3%) and TV repair was performed in 34 patients (60.7%). Overall 30-day mortality was 12.5%. Five-year survival was 63.9 ± 7.2% (95% confidence interval [CI]: 64.0-137.5 months). Freedom from reoperation for recurrent TV endocarditis was 91.7 ± 4.0% (95% CI: 152.3-179.3 months) at 5 years.  Blood culture is the most important tool to detect the causative pathogen causing IE of TV. The high risk of hepatitis C in patients with IVDA and IE of the TV should be mentioned.

摘要

本研究旨在评估因单纯三尖瓣心内膜炎接受三尖瓣(TV)手术患者的围手术期特征以及短期和中期结局。1995年6月至2012年2月期间,共有56例单纯三尖瓣心内膜炎患者在单一中心接受了TV手术。患者的平均年龄为53.8±17.1岁,男性39例(69.6%)。平均左心室射血分数为60.4±13.6%,13例(23.2%)患者患有糖尿病。平均逻辑欧洲心脏手术风险评估系统(EuroSCORE)为19.4±17.0%。平均随访时间为4.7±3.8年。微生物学检查显示,89.1%的患者血培养呈阳性,51.9%的患者术中拭子检查呈阳性。分离出的最常见病原体(42.9%)为 ,其次是凝固酶阴性葡萄球菌(17.9%)。11例患者(19.6%)有静脉药物滥用(IVDA)史,其中8例还患有丙型肝炎。共有15例患者(26.8%)植入了永久性起搏器/植入式心脏复律除颤器。22例患者(39.3%)进行了TV置换,34例患者(60.7%)进行了TV修复。总体30天死亡率为12.5%。5年生存率为63.9±7.2%(95%置信区间[CI]:64.0 - 137.5个月)。5年时,因复发性TV心内膜炎再次手术的无复发生存率为91.7±4.0%(95%CI:152.3 - 179.3个月)。血培养是检测导致TV心内膜炎病原体的最重要工具。应提及TV心内膜炎患者中IVDA患者丙型肝炎的高风险。

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