Department of Stomatology, Discipline of Integrated Clinical Dentistry, School of Dentistry, Univ de São Paulo, São Paulo, SP, Brazil.
Braz Oral Res. 2013 May-Jun;27(3):266-71. doi: 10.1590/S1806-83242013005000012. Epub 2013 Apr 19.
The objective of the study was to compare the analgesic effectiveness of dexamethasone and diclofenac sodium administered preemptively after surgical removal of third molars. Forty-four ASA (American Society of Anesthesiologists) I patients (19 men, 35 women; 16-28 years old) randomly and double-blindly received diclofenac sodium (50 mg) or dexamethasone (8 mg) or placebo 1 h before surgery. Intensity of pain, measured with a visual analog scale (VAS), was the variable studied at different postoperative times (1 h, 2 h, 3 h, 6 h, 8 h, 12 h, 48 h, 4 d and 7 d). The total amount of rescue medication (TARM) ingested (paracetamol) was another variable of the study. The Kruskal-Wallis statistical test was used. A p value of < .05 was adopted to reject the null hypothesis. The dexamethasone group showed lower pain intensity (p < .05) than the diclofenac sodium and placebo groups (p < .05). No difference in TARM was observed among the groups (p < .05). Preemptively administered, dexamethasone was effective in controlling postoperative pain.
本研究的目的是比较在第三磨牙切除术后预先给予地塞米松和双氯芬酸钠的镇痛效果。44 名 ASA（美国麻醉医师协会）I 级患者（男 19 名，女 35 名；16-28 岁）随机、双盲接受双氯芬酸钠（50mg）或地塞米松（8mg）或安慰剂，于术前 1 小时给药。疼痛强度采用视觉模拟评分（VAS）进行测量，研究在不同的术后时间点（1 小时、2 小时、3 小时、6 小时、8 小时、12 小时、48 小时、4 天和 7 天）进行。另一项研究变量为（扑热息痛）摄入的总解救药物量（TARM）。采用 Kruskal-Wallis 统计检验。p 值<.05 时拒绝零假设。地塞米松组的疼痛强度低于双氯芬酸钠组和安慰剂组（p<.05）。各组间 TARM 无差异（p<.05）。预先给予地塞米松可有效控制术后疼痛。
