Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, 187, Osong-eup, Cheongwon-gun, Chungcheongbuk-do, South Korea.
Division of High-Risk Pathogen Research, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, 187, Osong-eup, Cheongwon-gun, Chungcheongbuk-do, South Korea.
J Med Microbiol. 2013 Aug;62(Pt 8):1204-1210. doi: 10.1099/jmm.0.058164-0. Epub 2013 May 8.
We investigated changes in serotypes and antimicrobial susceptibilities among 386 isolates of invasive Streptococcus pneumoniae collected from numerous hospitals in Korea from 1996 to 2008. Serotypes 19F (9.8 %), 23F (8.3 %), 19A (7.8 %), 6A (7.5 %), 3 (7.3 %), 9V (6.5 %), 6B (6.2 %), 14 (4.9 %), 1 (3.9 %), 11A (3.9 %) and 4 (3.1 %) represented 69.2 % of all isolates. While the overall proportion of PCV7 serotypes was stable over time, we observed modest decreases in children <5 years old and in adults ≥65 years old between 1996-1999 and 2007-2008. An increased prevalence of non-PCV7 serotypes in these age groups was primarily attributable to an increase in serotypes 3, 6A and 19A. Most invasive S. pneumoniae isolates showed high resistance rates to erythromycin (74.9 %), tetracycline (71.1 %) and clindamycin (61.7 %). Between 1996-2003 and 2004-2008, non-susceptibility rates to cefotaxime and multi-drugs (three or more classes) in PCV7 serotypes showed a declining trend, while in non-PCV7 serotypes there was an increasing trend. Non-PCV7 serotypes 6A and 19A, which mostly exhibited multidrug-resistant phenotypes (69.0 % and 76.7 % respectively), increased between 1996-2003 and 2004-2008. Although PCV7 was introduced in Korea in November 2003, pneumococcal vaccination has not been included in the national child vaccination programme. Our results provide details of serotype occurrence that will be useful when adoption of universal pneumococcal vaccination in Korea is being considered.
我们调查了 1996 年至 2008 年期间从韩国多家医院采集的 386 株侵袭性肺炎链球菌的血清型和抗菌药物敏感性变化。血清型 19F（9.8%）、23F（8.3%）、19A（7.8%）、6A（7.5%）、3（7.3%）、9V（6.5%）、6B（6.2%）、14（4.9%）、1（3.9%）、11A（3.9%）和 4（3.1%）占所有分离株的 69.2%。虽然 PCV7 血清型的总体比例随时间保持稳定，但我们观察到 1996-1999 年至 2007-2008 年期间 5 岁以下儿童和 65 岁以上成人中 PCV7 血清型的比例适度下降。这些年龄组中非 PCV7 血清型的流行率增加主要归因于血清型 3、6A 和 19A 的增加。大多数侵袭性肺炎链球菌分离株对红霉素（74.9%）、四环素（71.1%）和克林霉素（61.7%）表现出较高的耐药率。1996-2003 年和 2004-2008 年期间，PCV7 血清型对头孢噻肟和多种药物（三种或更多类）的非敏感性率呈下降趋势，而非 PCV7 血清型则呈上升趋势。非 PCV7 血清型 6A 和 19A 主要表现出多药耐药表型（分别为 69.0%和 76.7%），在 1996-2003 年和 2004-2008 年期间有所增加。尽管 PCV7 于 2003 年 11 月在韩国推出，但肺炎球菌疫苗接种尚未纳入国家儿童疫苗接种计划。我们的研究结果提供了血清型发生的详细信息，这在考虑在韩国实施普遍肺炎球菌疫苗接种时将非常有用。
