Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Chungnam National University Hospital, Daejeon, Republic of Korea.
Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Diagn Microbiol Infect Dis. 2014 Apr;78(4):481-6. doi: 10.1016/j.diagmicrobio.2013.12.016. Epub 2014 Jan 7.
This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.
本研究调查了 2006 年至 2010 年期间韩国儿童侵袭性感染中肺炎球菌分离株的血清型分布和抗生素耐药性，当时 7 价肺炎球菌结合疫苗（PCV7）作为一种可选疫苗提供。在从 8 个中心收集的 140 株分离株中，常见的血清型为 19A（22.9%）、19F（12.1%）和 6B（8.6%）。2006 年至 2010 年间，PCV7 血清型从 62.5%下降至 21.4%（P=0.002），而三种 13 价肺炎球菌结合疫苗（PCV13）特异性血清型（3、6A 和 19A）从 18.8%上升至 42.9%（P=0.016）。在 102 株多药耐药分离株中，PCV7 血清型的比例从 65.2%下降至 21.7%（P=0.001），3 种 PCV13 特异性血清型的比例从 17.4%上升至 47.8%（P=0.008）。可选的 PCV7 疫苗接种影响了韩国 PCV7 血清型的比例，导致其下降，而 3 种 PCV13 特异性血清型，特别是 19A 的比例增加。
