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Hetlaxin, a new toxin from the Heterometrus laoticus scorpion venom, interacts with voltage-gated potassium channel Kv1.3.

作者信息

Anh Hoang Ngoc, Hoang Vo Do Minh, Kudryashova K S, Nekrasova O V, Feofanov A V, Andreeva T V, Tsetlin V I, Utkin Yu N

机构信息

Institute of Applied Materials Sciences, Vietnamese Academy of Science and Technology, Ho Chi Minh City, Vietnam.

出版信息

Dokl Biochem Biophys. 2013 Mar-Apr;449:109-11. doi: 10.1134/S1607672913020142. Epub 2013 May 9.

DOI:10.1134/S1607672913020142
PMID:23657660
Abstract
摘要

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Fluorescent system based on bacterial expression of hybrid KcsA channels designed for Kv1.3 ligand screening and study.基于细菌表达杂合 KcsA 通道的荧光系统，专为 Kv1.3 配体筛选和研究设计。
Anal Bioanal Chem. 2013 Mar;405(7):2379-89. doi: 10.1007/s00216-012-6655-6. Epub 2013 Jan 11.
2
Studying of Membrane Localization of Recombinant Potassium Channels in E.coli.研究重组钾通道在大肠杆菌中的膜定位。
Acta Naturae. 2009 Apr;1(1):91-5.
3
Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily.
海拉毒素 1（ Heterometrus laoticus ）的纯化、分子克隆及功能特征鉴定：新型 κ-KTX 亚家族的首个成员。
Biochem Pharmacol. 2012 May 1;83(9):1307-17. doi: 10.1016/j.bcp.2012.01.021. Epub 2012 Jan 24.
4
Recombinant Kv channels at the membrane of Escherichia coli bind specifically agitoxin2.大肠杆菌细胞膜上的重组钾离子通道特异性结合阿吉毒素2。
J Neuroimmune Pharmacol. 2009 Mar;4(1):83-91. doi: 10.1007/s11481-008-9116-4. Epub 2008 Jul 23.
5
Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom.老挝异距蝎毒液中异蝎毒素-1（HS-1）的纯化与鉴定
Toxicon. 2007 Jan;49(1):19-29. doi: 10.1016/j.toxicon.2006.09.003. Epub 2006 Sep 14.
6
Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA.将钾通道肽基抑制剂的工程特异性药理结合位点导入KcsA。
Biochemistry. 2002 Dec 24;41(51):15369-75. doi: 10.1021/bi026264a.
7
Modulation of K+ currents in monocytes by VCAM-1 and E-selectin on activated human endothelium.活化的人内皮细胞上的血管细胞黏附分子-1（VCAM-1）和E-选择素对单核细胞钾离子电流的调节作用。
Am J Physiol. 1998 Jul;275(1):C267-77. doi: 10.1152/ajpcell.1998.275.1.C267.